ID   A0A344UBQ2_9ACTN        Unreviewed;       756 AA.
AC   A0A344UBQ2;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Pyridoxal-5'-phosphate-dependent protein {ECO:0000313|EMBL:AXE28323.1};
GN   ORFNames=C0216_31660 {ECO:0000313|EMBL:AXE28323.1};
OS   Streptomyces globosus.
OG   Plasmid unnamed2 {ECO:0000313|EMBL:AXE28323.1,
OG   ECO:0000313|Proteomes:UP000252004}.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=68209 {ECO:0000313|EMBL:AXE28323.1, ECO:0000313|Proteomes:UP000252004};
RN   [1] {ECO:0000313|EMBL:AXE28323.1, ECO:0000313|Proteomes:UP000252004}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LZH-48 {ECO:0000313|EMBL:AXE28323.1,
RC   ECO:0000313|Proteomes:UP000252004};
RC   PLASMID=unnamed2 {ECO:0000313|EMBL:AXE28323.1,
RC   ECO:0000313|Proteomes:UP000252004};
RA   Ran K., Li Z., Wei S., Dong R.;
RT   "Draft genome Sequence of streptomyces globosus LZH-48.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR   EMBL; CP030864; AXE28323.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A344UBQ2; -.
DR   KEGG; sgz:C0216_31660; -.
DR   OrthoDB; 24041at2; -.
DR   Proteomes; UP000252004; Plasmid unnamed2.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProt.
DR   CDD; cd01561; CBS_like; 1.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   Gene3D; 3.40.50.20; -; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR041472; BL00235/CARNS1_N.
DR   InterPro; IPR040570; LAL_C2.
DR   InterPro; IPR001926; TrpB-like_PALP.
DR   InterPro; IPR036052; TrpB-like_PALP_sf.
DR   PANTHER; PTHR10314; CYSTATHIONINE BETA-SYNTHASE; 1.
DR   PANTHER; PTHR10314:SF194; CYSTATHIONINE BETA-SYNTHASE; 1.
DR   Pfam; PF13535; ATP-grasp_4; 1.
DR   Pfam; PF18130; ATPgrasp_N; 1.
DR   Pfam; PF18603; LAL_C2; 1.
DR   Pfam; PF00291; PALP; 1.
DR   SMART; SM01209; GARS_A; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Plasmid {ECO:0000313|EMBL:AXE28323.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Reference proteome {ECO:0000313|Proteomes:UP000252004}.
FT   DOMAIN          457..656
FT                   /note="ATP-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS50975"
SQ   SEQUENCE   756 AA;  79434 MW;  DFF3B3060BAED045 CRC64;
     MIFESMNDAV GNTPLVRLDV PASEGTQVYA KLELANAFGM KDRVARNIVS EARRLGVLRP
     GAPIVESSSG TMALGVALVG RSLGHPVHIV TDPRTDPTTL AKLRALGCEV HVVAAMADGG
     WQGARLDRLA ELMRELPGAF WPQQYSNPDN PGAYRVLAAE LLADLGPLDA LVGAVGSGGS
     LCGTGRALRR SLPGLRVVGV DSVGSTLFDQ PDVPGRLQSG LGNSLHPNNL DRTAIDEIHW
     LNDREAFAAT RELAREQQIF AGNTSGSVYR VLRHLALTAE PGSRIVGIFP DRGDRYTETV
     YSDEHWAVHR LEELACSDAP VPVEYGTPVR SWSSAGLGGR PAGPRHLLFV EANTSGTGVQ
     ALGTAAGLGL TAVLLTSNPD RYAGAAETGC RIVVCDTNDA SALRRTIQER FRREEIAGIT
     TTSDFYVPAV AALAEWLGLP GNDEAAANRC RNKAELRRTL EAAGVPQPRF AVVTDAARAE
     EAAASVGLPC VVKPADDSGS NDVLLCSTAA EAAVHAARIL AVETNVRGLP TARTVLVEEY
     LDAPEYSVEM FGDGGDAVCV GVTAKHLTGI PYFVEAGHDF PAPLQEAERA ALVDAVTRAL
     KAAGMRFGPT HTEVKLTARG PAVIEINPRL AGGMIPELIR LATGSDLLEQ QIRAAAGLPV
     DLAARRSGHA GIRFLLADRP GTLASVDGTG EALAAEGVER VTVTAAAGRP VRPPQNAYDR
     LGHVIVRGDD AAQVAAALGA ARQHITVRLD ADASAK
//