ID A0A345E0G4_9EURY Unreviewed; 561 AA.
AC A0A345E0G4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149,
GN ECO:0000313|EMBL:AXG05686.1};
GN ORFNames=DU500_04120 {ECO:0000313|EMBL:AXG05686.1};
OS Haloplanus rubicundus.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloplanus.
OX NCBI_TaxID=1547898 {ECO:0000313|EMBL:AXG05686.1, ECO:0000313|Proteomes:UP000253273};
RN [1] {ECO:0000313|EMBL:AXG05686.1, ECO:0000313|Proteomes:UP000253273}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBA1113 {ECO:0000313|EMBL:AXG05686.1,
RC ECO:0000313|Proteomes:UP000253273};
RA Kim Y.B., Roh S.W.;
RT "Genome sequences of Haloplanus sp. CBA1113.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; CP031150; AXG05686.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A345E0G4; -.
DR KEGG; haj:DU500_04120; -.
DR OrthoDB; 146201at2157; -.
DR Proteomes; UP000253273; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Endonuclease {ECO:0000313|EMBL:AXG05686.1};
KW Hydrolase {ECO:0000313|EMBL:AXG05686.1};
KW Nuclease {ECO:0000313|EMBL:AXG05686.1}.
FT DOMAIN 216..342
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 375..514
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 108..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 59192 MW; E89136729EB5821C CRC64;
MRRLDRETVD RIAAGEVVTR PARVVEELVE NALDAGAERI EIEVDGDGTE RIRVADDGRG
MSADEAELAV ERHTTSKLPD GDLTAVETLG FRGEALASIA DVARMTLTTN DGGPRGTSVH
VDGAGPRSAG SRPAAGDDVT VDSAGRGRGT TVEVRDLFHN RPARAESLAA PATEFERISD
RVAAYALLRP DVALSLEHDG RRVFATPGSG DAADAALSVY GREVARESTT VDATATATVG
DEKATVELRG LLAYPSITRA SADHVRIAVN GRPVSVPALR RAVERGYGSL LAGDRHPVVA
LAVSLPPWAV DPNVHPTKQT VALRAADAVA GVVEDAVSDA LSTADLRRSA DVAMDLDAAL
DPVDTAASAL DDATVLGRFR DLYLLCEADD DLLVIDQHAA HERINYERLR AAVESEGVES
VPLDPPATLS LSPGQVAAVE SHADELERLG FDCEPFGGGT VRVRAVPAPL GRVAAPDTLE
STLTALREGE DPNRRDELLA DLACHPSLKA GDELTDDDAA ALVERLGACE QPFACPHGRP
TVLAIDEGHL ARGFERHPRR G
//
