ID   A0A345GYI3_9FLAO        Unreviewed;       312 AA.
AC   A0A345GYI3;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Hydroxypyruvate reductase {ECO:0000313|EMBL:AXG69371.1};
DE            EC=1.1.1.81 {ECO:0000313|EMBL:AXG69371.1};
GN   ORFNames=KORDIASMS9_01591 {ECO:0000313|EMBL:AXG69371.1};
OS   Kordia sp. SMS9.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Kordia.
OX   NCBI_TaxID=2282170 {ECO:0000313|EMBL:AXG69371.1, ECO:0000313|Proteomes:UP000253780};
RN   [1] {ECO:0000313|EMBL:AXG69371.1, ECO:0000313|Proteomes:UP000253780}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMS9 {ECO:0000313|EMBL:AXG69371.1,
RC   ECO:0000313|Proteomes:UP000253780};
RA   Topel M., Pinder M.I.M., Johansson O.N., Kourtchenko O., Clarke A.K.,
RA   Godhe A.;
RT   "Genome Sequence of Kordia sp. Strain SMS9 Isolated from a Culture of the
RT   Diatom Skeletonema marinoi.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR   EMBL; CP031153; AXG69371.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A345GYI3; -.
DR   KEGG; kos:KORDIASMS9_01591; -.
DR   OrthoDB; 9805416at2; -.
DR   Proteomes; UP000253780; Chromosome.
DR   GO; GO:0016618; F:hydroxypyruvate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   CDD; cd12179; 2-Hacid_dh_14; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003719,
KW   ECO:0000313|EMBL:AXG69371.1}; Pyruvate {ECO:0000313|EMBL:AXG69371.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253780}.
FT   DOMAIN          24..308
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          105..289
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   312 AA;  34700 MW;  8676EF9EA5A1BED0 CRC64;
     MNILHLDENH PLLLEQFAAL GHTNHEDYTS SKAEIAAKIK NYDGFIIRSR FKIDADFLAK
     ATNLKFIGRV GAGLENIDGE FAAAKGIKLI AAPEGNRNAV GEHALGMLLS LMNKLNKGDQ
     EVRDGKWLRE ANRGVELDGQ TVGIIGYGNM GKAFAKKLRG FEVEVLFYDL KENIGDENAT
     QVSLAELQKR ATVLSLHTPQ TPLTMNMINK EFIEAFQHQF WFINTARGKS VVTQDLVAAL
     QSGKILGAGL DVLEYEKSSF ENLFQDDQMP AAFQYLIQAQ NVLLSPHVAG WTVESKEKLA
     QTIVDKFKVH FH
//