ID A0A345HF48_9FLAO Unreviewed; 587 AA.
AC A0A345HF48;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Aromatic amino acid hydroxylase {ECO:0000313|EMBL:AXG75208.1};
GN ORFNames=DVK85_02935 {ECO:0000313|EMBL:AXG75208.1};
OS Flavobacterium arcticum.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1784713 {ECO:0000313|EMBL:AXG75208.1, ECO:0000313|Proteomes:UP000253951};
RN [1] {ECO:0000313|EMBL:AXG75208.1, ECO:0000313|Proteomes:UP000253951}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SM1502 {ECO:0000313|EMBL:AXG75208.1,
RC ECO:0000313|Proteomes:UP000253951};
RA Li Y., Li D.-D.;
RT "Complete genome sequence of Flavobacterium arcticum type strain SM1502T.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR EMBL; CP031188; AXG75208.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A345HF48; -.
DR KEGG; fat:DVK85_02935; -.
DR OrthoDB; 9780502at2; -.
DR Proteomes; UP000253951; Chromosome.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR CDD; cd00361; arom_aa_hydroxylase; 1.
DR Gene3D; 1.20.58.690; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR Pfam; PF00351; Biopterin_H; 2.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601273-2};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000253951}.
FT DOMAIN 1..342
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 131
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 136
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 221
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ SEQUENCE 587 AA; 65560 MW; A4EBDAEB04FD7E42 CRC64;
MSATIDSNPL LDKLPEHLRQ FIKPQDYKDY TPINQAVWRY VMRKNVDYLS KVAHNSYLEG
LEKTGIEVDN IPSMYGMNRI LKEIGWAAVA VDGFIPPNAF MEFQAYNVLV IASDIRQLEH
IEYTPAPDII HEGAGHAPII ANPEYAEYLR RFGEIGCKAI SSARDYEMYE AIRLLSILKE
AEGTPQDEID AIEKRVEDLQ NDMGELSEMA LVRNLHWWTV EYGLIGTVDD PKIYGAGLLS
SIGESAWCMT DNVKKMPYDI NAAYQSFDIT KPQPQLYVTP DFAHLNQVLE EFANKMALRT
GGLSGLTKLI QSNALGTIEL STGLQVSGTF TNVIQDNGKP IYIQTTGATA LSYREKELVG
HGTLYHAEGF GSPVGKLKGI NLAIEDMSPR DLQAYDIYEG GRVTLEFEGG VKVSGEIITG
TRNLQGKIII ISFKDCTVTH NDTVLFQPEW GIYDMAVGKK VIAAFSGPAD VTSFDLITHV
PSSQTIKAKK SPAREELEGL YQKVRGIREG KADNKELQSI FTIVKQNHPN DWLLSVEIAE
LLQKNNTTEL LNQVMTHLDD VKNRRPEIVH LVDGGLELIF EKEKSLD
//
