ID   A0A345HK62_9ACTN        Unreviewed;       696 AA.
AC   A0A345HK62;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Protein-L-isoaspartate O-methyltransferase {ECO:0000256|ARBA:ARBA00013346};
DE            EC=2.1.1.77 {ECO:0000256|ARBA:ARBA00011890};
DE   AltName: Full=L-isoaspartyl protein carboxyl methyltransferase {ECO:0000256|ARBA:ARBA00031350};
DE   AltName: Full=Protein L-isoaspartyl methyltransferase {ECO:0000256|ARBA:ARBA00030757};
DE   AltName: Full=Protein-beta-aspartate methyltransferase {ECO:0000256|ARBA:ARBA00031323};
GN   Name=fxlM {ECO:0000313|EMBL:AXG77086.1};
GN   ORFNames=DVK44_04640 {ECO:0000313|EMBL:AXG77086.1};
OS   Streptomyces paludis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2282738 {ECO:0000313|EMBL:AXG77086.1, ECO:0000313|Proteomes:UP000253868};
RN   [1] {ECO:0000313|Proteomes:UP000253868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GSSD-12 {ECO:0000313|Proteomes:UP000253868};
RA   Zhao J.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC       isoaspartyl/D-aspartyl protein methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005369}.
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DR   EMBL; CP031194; AXG77086.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A345HK62; -.
DR   KEGG; spad:DVK44_04640; -.
DR   OrthoDB; 4035289at2; -.
DR   Proteomes; UP000253868; Chromosome.
DR   GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR027573; Methyltran_FxLD.
DR   InterPro; IPR000682; PCMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR023809; Thiopep_bacteriocin_synth_dom.
DR   NCBIfam; TIGR04364; methyltran_FxLD; 1.
DR   NCBIfam; TIGR03891; thiopep_ocin; 1.
DR   PANTHER; PTHR11579; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11579:SF0; PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE; 1.
DR   Pfam; PF14028; Lant_dehydr_C; 1.
DR   Pfam; PF01135; PCMT; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000313|EMBL:AXG77086.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253868};
KW   Transferase {ECO:0000313|EMBL:AXG77086.1}.
FT   DOMAIN          17..259
FT                   /note="Thiopeptide-type bacteriocin biosynthesis"
FT                   /evidence="ECO:0000259|Pfam:PF14028"
SQ   SEQUENCE   696 AA;  76055 MW;  EC857DDF55EEC760 CRC64;
     MAPDEWRQRV IRFTDWDRAE HTAVKHLIPV LTAADTEPHQ WSFLRKFPSW RLRYRPAGPD
     RTKRLDAALD ELVTAGVLVS WTPGIHEPEE TVFGGPAAME IAHALFHQDS IQLLAQLTRE
     QAASGPGLAR RELGVLLLSV AMRAAGLDWY EQGDVWARIA AERPGCEVRH SERHKAAVHR
     LMTIDVSPSS RVVTDGRLAP VADWTVTFEC LGRQLGDLNR QGRLERGLRA VFAHHGIFHW
     NRLGLPAEDQ HTLSTLAKEV VMGTSDNAAS TRTGGVRSTT VDGVNSETVE ASSADRLRAQ
     LIDHLVDEGS VRTPRVEEAM RTVPRHLFVP NAPLEKAYGN APVNTKFDES GASISCASQP
     DIVGMMLEQL EAEPDQKILE LGAGTGFNAG LLGHLVGEKG HVTTIDVDQD IVDGARAGLA
     AAGIHNVEVI LGDGAVGHAP NAPYDRIVAT VGAHGVPHAW LDQLAPGGRL LTPLRLRGSV
     SRSIAFEQRD RAWRSVGSEM NTFMPLRRGI ADDPRVFVPL DPDNTVTLVT NGDQAADPDA
     LSDVFRRPRA EVWTGVTFRG PESAEYLELW LTCTMPNGLS RMPAKPEALR SGLVTAPYAS
     STAVFEGSTL TYLTRRQAAE KAPDGATLYE FGVIGHGPDG ETLARDVSDQ VRAWDRDFRS
     RDVGFEIQPL GAAPLASKPG RFTFDNELNR IVIEWQ
//