ID A0A345HQH8_9ACTN Unreviewed; 510 AA.
AC A0A345HQH8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AXG78952.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:AXG78952.1};
GN ORFNames=DVK44_15995 {ECO:0000313|EMBL:AXG78952.1};
OS Streptomyces paludis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2282738 {ECO:0000313|EMBL:AXG78952.1, ECO:0000313|Proteomes:UP000253868};
RN [1] {ECO:0000313|Proteomes:UP000253868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GSSD-12 {ECO:0000313|Proteomes:UP000253868};
RA Zhao J.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009463}.
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DR EMBL; CP031194; AXG78952.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A345HQH8; -.
DR KEGG; spad:DVK44_15995; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000253868; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR041040; 3HCDH_RFF.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF18321; 3HCDH_RFF; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00067; 3HCDH; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:AXG78952.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253868}.
FT DOMAIN 10..187
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 190..287
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 354..419
FT /note="3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-
FT fold"
FT /evidence="ECO:0000259|Pfam:PF18321"
FT DOMAIN 420..503
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 510 AA; 53527 MW; A888502B3AF73A07 CRC64;
MTAIEPHRVV AVVGTGTMGQ GIAQVALAAG HPVRLYDAAP GLAAQAATAI AGRLDRQVAK
GRLHAASRDA ALARLRPADS LAELSDAALV AEAVVERLPV KQELFAALED TVADGCLLAT
NTSSLSVTAV AGALRLPGRL VGLHFFNPAP LLPLVEVVSG AATDPAAADR AYATARAWGK
TPVRCADTPG FIVNRVARPF YAEALRVYEE GAADPATIDA VLRECGGFRM GPFELMDLIG
QDVNETVTRS VWESFHQDVR FTPSLAQRRL VEAGRLGRKS GRGWFAYGPE TEGTRACPRT
EEPCEAPDAV GLHADLGPAA VLREMIEEAG IKVTRDRTPH ISGGFIALPG GTALALTDGA
TPTADPSGAY IHFDLALDYR ACTRIALAPG ADADPADLRA AIGLFQRLGK QVSVIGEIPG
MIVARTVAML IDFAADAAGR AVASARDIDT AMKLGVNYPG GPGEWCARLG AGWAHYFLRT
MDGEYPGGRY GSSPALRRRA ELEAKQGRSS
//
