ID   A0A345HRQ6_9ACTN        Unreviewed;       323 AA.
AC   A0A345HRQ6;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE            EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN   ORFNames=DVK44_18915 {ECO:0000313|EMBL:AXG79380.1};
OS   Streptomyces paludis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2282738 {ECO:0000313|EMBL:AXG79380.1, ECO:0000313|Proteomes:UP000253868};
RN   [1] {ECO:0000313|Proteomes:UP000253868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GSSD-12 {ECO:0000313|Proteomes:UP000253868};
RA   Zhao J.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP031194; AXG79380.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A345HRQ6; -.
DR   KEGG; spad:DVK44_18915; -.
DR   OrthoDB; 9774633at2; -.
DR   Proteomes; UP000253868; Chromosome.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR   Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR   InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR   InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR   InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR   InterPro; IPR000398; Thymidylate_synthase.
DR   PANTHER; PTHR11548:SF9; THYMIDYLATE SYNTHASE; 1.
DR   PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253868};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          56..227
FT                   /note="Thymidylate synthase/dCMP hydroxymethylase"
FT                   /evidence="ECO:0000259|Pfam:PF00303"
SQ   SEQUENCE   323 AA;  36164 MW;  1F3F35D00BF2814B CRC64;
     MTHLTGDSVA ELFTGAVLLA KAGEEVAPRG MATREVLNVT MTLAQPRARL LYAPPTRILN
     PAFAVAETVW HLSGSDEPWI YDYNARLRQF TDDGILRGAY GPRMRNWAGT VDQLRRVVEI
     LKEDRDSRRA LIQLYDPARD AAGHKDVPCT LGFRFHLRAG RLHMTTSMRG QDVWIGMPYD
     LFFFTTLHEL VAGWLDADLG EYHHQVGSLH IYERDMERAD TLTDVTASTV MPELATPWEG
     FDKLLAKVGA REETGHPGWA AMADTMCSYR LWKDGLREQA WRVADTIDTP LGEALIAWYG
     ELVRRTGTST ARTIPTSAGT GTM
//