ID A0A345HRX9_9ACTN Unreviewed; 800 AA.
AC A0A345HRX9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Cu(2+)-exporting ATPase {ECO:0000313|EMBL:AXG79453.1};
GN ORFNames=DVK44_19360 {ECO:0000313|EMBL:AXG79453.1};
OS Streptomyces paludis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2282738 {ECO:0000313|EMBL:AXG79453.1, ECO:0000313|Proteomes:UP000253868};
RN [1] {ECO:0000313|Proteomes:UP000253868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GSSD-12 {ECO:0000313|Proteomes:UP000253868};
RA Zhao J.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
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DR EMBL; CP031194; AXG79453.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A345HRX9; -.
DR KEGG; spad:DVK44_19360; -.
DR OrthoDB; 7059309at2; -.
DR Proteomes; UP000253868; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01229; COF_2; 1.
DR PROSITE; PS01047; HMA_1; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Cell membrane {ECO:0000256|RuleBase:RU362081};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000253868};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 131..149
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 155..172
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 192..215
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 235..253
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 387..409
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 415..436
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 752..768
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 774..791
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 9..74
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 70..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 800 AA; 82056 MW; FE5125B896FB4C2B CRC64;
MSATQTSGTD VELTIGGMTC ASCAARIEKK LNRMEGVEAT VNYATEKAKV TYRGEDVSVR
DLIATVEATG YTAKEPPPRY PTGPRSTPSS YGAEAADGAD GAGAAGATAV HPDATDDDAD
DPELISLRQR LLTAVILAVP VIAMAMVPAL QFDNWQWLSL TLAAPVVVYA GWPFHRAAWT
NARHGAATMD TLISVGTWAA FLWSLWALFF GTAGMHGMRH PFELTISRGG ASGNIYLEAA
AGVTAFILAG RYFEIRAKRK AGAALRALLE LGAKEVTVIR EGRELRVPTA DLQAGDVFLV
RPGEKIATDG VVVEGSSAVD ASMLTGESVP VEVSAGDPVT GATLNAGGRL VVRATRIGAD
TQLARMARMV EDAQNGKAAV QRLADRISAV FVPVVMVLAL GTLGVWLATG AGLTAAFTAA
VAVLIIACPC ALGLATPTAL MVGTGRGAQL GILIKGPEVL ESTRKVDTIV LDKTGTVTTG
RMTLLATHTA AADGARGSDR SGDSGGDTSG ADAAETQVLR LAGALEHASE HPIARAVAEG
AAERVGALPT PVDFANVPGL GVQGTVEGHA VLVGRPKLLA DRGIGLPAGL DRARTDAEAA
GRTVIAVAWD GEARAVLEVA DAVKETSAEA VGRLRALGLT PILLTGDNKA VAAAVAAEVG
IDASDVIAEV MPEDKVEVVK KLQAEGRSVA MVGDGVNDAA ALAQADLGLA MGTGTDAAIE
AGDLTLVRGD LRTAADAIRL ARRTLGTIRG NLFWAFAYNV AAIPLAAAGL LNPMIAGAAM
AFSSVFVVGN SQRLRGFKAV
//
