ID A0A345HS75_9ACTN Unreviewed; 1042 AA.
AC A0A345HS75;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=AfsR family transcriptional regulator {ECO:0000313|EMBL:AXG79549.1};
GN ORFNames=DVK44_19970 {ECO:0000313|EMBL:AXG79549.1};
OS Streptomyces paludis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2282738 {ECO:0000313|EMBL:AXG79549.1, ECO:0000313|Proteomes:UP000253868};
RN [1] {ECO:0000313|Proteomes:UP000253868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GSSD-12 {ECO:0000313|Proteomes:UP000253868};
RA Zhao J.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
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DR EMBL; CP031194; AXG79549.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A345HS75; -.
DR KEGG; spad:DVK44_19970; -.
DR OrthoDB; 3845029at2; -.
DR Proteomes; UP000253868; Chromosome.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 5.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01091}; Reference proteome {ECO:0000313|Proteomes:UP000253868};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 74..170
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 74..170
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1042 AA; 111503 MW; 747829398FFFA212 CRC64;
MERDGEPRVP EQRERRAPVG TEGTKGGRAG DGASEDAGVR ASKNAGADAT AQGDANGNAS
AGTSAHTNAG PGATAHPSTD ALRFSVLGPV RAWRGAETLP SGSPQQRALL AALLLREGRT
ATAPELIDAL WGDRPPSQAL AAVRTYASRL RKVLSSGVLV SESGGYALRT GPEALDLSVA
EELAGHADKE RAAGNRAQAR DLLNRSLELW TGEPLAAVPG PYAQTQRARL EEWRLQLTEA
RIDMDLEAGC HAGAVSELTA LTAEHPLRER LRELLMLALY RGGRQAEALA VYADTRRLLA
DELGVDPRPE LARLHQRILE ADALLVGPAE EPATSPAVLR PAQLPATVPD FTGRAAFVQE
LGDRLATPEG AVMAVSAIAG IGGVGKTTLA IHVAHAARAH FPDGQLYVDL QGAGPRAAEP
ETVLASFLRA LGMSAAAIPD SLEDRSALYR STLDGRRVLV LLDNARDAAQ VRPLLPGTDG
CAAVVTSRGR MVDLAGAHLV DLDVMSPDEA LQLFTRIIGH ERVSSEREAA LDVVAACGFL
PLAIRIAASR IASRRTWTVS VLAEKLADER RRLDELQAGD LAVKATFELG YGALEQSQAR
AFRLLGLADG PDISLAAAAA LLDLPVRQAE ELLESLVDTS LLESAAPGRY RYHDLVRLYA
RACAERDEQP ASRREDALSR LLDFYLATTA NVYALERPGD RLPDRLEATA YPGLSFTDRR
DGEDWLYAEA NSVLACAHQA ADRPGTLRRA VDLLWASLDL GESGANSKEY EEAAAALLTA
AGASGDPWLE GRALITMSNV HHFTGRFDRA KEKAEQARAL AHHSGDLLTM AWASNHCGII
ALYQNRYPDG ERHLTRAIAD YRADGNEAGE ASSLCNLSRV RLALGRTASA IALAQQGMEI
YDRTGNTLRG ANARYALGMA LAQKDHLTDA TDRLTEALKT FRDSRHRLWE GMSLFRLAEV
DLLARRPVRA ASNAEAALTI LRDIGGDWRR ANVLTTLGRA LNSIGQTGRA HVCWREALAT
YEELGSPEAA DVRALLSSVA AA
//
