ID A0A345HT74_9ACTN Unreviewed; 425 AA.
AC A0A345HT74;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Thymidine phosphorylase {ECO:0000313|EMBL:AXG79898.1};
DE EC=2.4.2.4 {ECO:0000313|EMBL:AXG79898.1};
GN ORFNames=DVK44_22100 {ECO:0000313|EMBL:AXG79898.1};
OS Streptomyces paludis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2282738 {ECO:0000313|EMBL:AXG79898.1, ECO:0000313|Proteomes:UP000253868};
RN [1] {ECO:0000313|Proteomes:UP000253868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GSSD-12 {ECO:0000313|Proteomes:UP000253868};
RA Zhao J.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC phosphorylase family. {ECO:0000256|ARBA:ARBA00006915}.
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DR EMBL; CP031194; AXG79898.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A345HT74; -.
DR KEGG; spad:DVK44_22100; -.
DR OrthoDB; 9763887at2; -.
DR Proteomes; UP000253868; Chromosome.
DR GO; GO:0004645; F:1,4-alpha-oligoglucan phosphorylase activity; IEA:InterPro.
DR GO; GO:0016154; F:pyrimidine-nucleoside phosphorylase activity; IEA:InterPro.
DR GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR GO; GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro.
DR Gene3D; 3.40.1030.10; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR Gene3D; 3.90.1170.30; Pyrimidine nucleoside phosphorylase-like, C-terminal domain; 1.
DR InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom.
DR InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom_sf.
DR InterPro; IPR035902; Nuc_phospho_transferase.
DR InterPro; IPR036566; PYNP-like_C_sf.
DR InterPro; IPR013102; PYNP_C.
DR InterPro; IPR018090; Pyrmidine_PPas_bac/euk.
DR InterPro; IPR017872; Pyrmidine_PPase_CS.
DR InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR NCBIfam; TIGR02644; Y_phosphoryl; 1.
DR PANTHER; PTHR10515; THYMIDINE PHOSPHORYLASE; 1.
DR PANTHER; PTHR10515:SF0; THYMIDINE PHOSPHORYLASE; 1.
DR Pfam; PF02885; Glycos_trans_3N; 1.
DR Pfam; PF00591; Glycos_transf_3; 1.
DR Pfam; PF07831; PYNP_C; 1.
DR PIRSF; PIRSF000478; TP_PyNP; 1.
DR SMART; SM00941; PYNP_C; 1.
DR SUPFAM; SSF52418; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR SUPFAM; SSF47648; Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain; 1.
DR SUPFAM; SSF54680; Pyrimidine nucleoside phosphorylase C-terminal domain; 1.
DR PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:AXG79898.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253868};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AXG79898.1}.
FT DOMAIN 334..408
FT /note="Pyrimidine nucleoside phosphorylase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00941"
SQ SEQUENCE 425 AA; 44101 MW; 3844E65BFAC5AC1D CRC64;
MDVISVIRTK RDRGELSPEQ IDWVIDAYTR GEVADEQMSA LAMAILLNGM NRTEIARWTA
AMIASGERMD FSALSRPTAD KHSTGGVGDK ITLPLAPLVA ACGAAVPQLS GRGLGHTGGT
LDKLESIPGW RALLSNEEML HVLDTTGAVI CAAGDGLAPA DKKLYALRDV TGTVEAIPLI
ASSIMSKKIA EGTGSLVLDV KVGTGAFMKT IEDARELAAT MVGLGTDHGV KTVALLTDMA
TPLGLTAGNA LEVRESVEVL AGGGPADVVE LTLALAREML DAAGLPDADP AKALADGSAM
DVWRRMIAAQ GGDPDAALPV ARERQTITAP ASGVLTRLDA YGVGVAAWRL GAGRARKEDP
VQAGAGIEIH AKPGDRVTEG QPLLTLHTDT PEKFAYATEA LEGTYDIGAA GTAYEATPVV
RERIA
//
