ID A0A345KWL5_9CAUD Unreviewed; 607 AA.
AC A0A345KWL5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=DNA polymerase I {ECO:0000313|EMBL:AXH47417.1};
GN Name=53 {ECO:0000313|EMBL:AXH47417.1};
GN ORFNames=SEA_HANGMAN_53 {ECO:0000313|EMBL:AXH47417.1};
OS Mycobacterium phage Hangman.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Bclasvirinae; Coopervirus; Coopervirus brownCNA.
OX NCBI_TaxID=2250299 {ECO:0000313|EMBL:AXH47417.1, ECO:0000313|Proteomes:UP000257782};
RN [1] {ECO:0000313|EMBL:AXH47417.1, ECO:0000313|Proteomes:UP000257782}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Akers M.E., Baldus K., Bryant G.N., Cevasco M.E., Chichester A.M.,
RA Largen K.M., Lehmann E.J., Majewski M., Pires N., Ricci K.D., Smith R.L.,
RA Tancini M.E., Williams D.C., Butela K.A., Garlena R.A., Russell D.A.,
RA Pope W.H., Jacobs-Sera D., Hatfull G.F.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; MH513970; AXH47417.1; -; Genomic_DNA.
DR Proteomes; UP000257782; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00023109};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 392..570
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 607 AA; 66742 MW; E26F6BC610E4532C CRC64;
MTTTAIPRVP SRSWYDPVLD ATMHTGANAV RAADQFCTRL PHRSTPIAFD IETPGLDNVF
TINCVTAAWD WPDGGTQTIL LDPARDEEHY EVAVALLHAA RTVAFHNVPF DAPPLYHAGL
INDNTIRRIV DTLLITRFAV PDVMVPKNLT ALSVRHLGLD DDKGGLERAF KAAGYKTQQA
GFEGMDITSP VYRYGAMADT VATLRVEPLM RAKALHWATD HPFATYGATT VGEAEELLAT
QETVHRVMLR RSAVGLAVDR AYLDRYAEQV DIDRNLAIAE LAAHGLEGGS GKGAKLVEYL
HERGELPANW PRTPTKKLRA TKADLDGLDH PLAAAQRKLA QIDKVMGYLE KVSRQASVTG
RCHPQVSTLG ASATGRMAYG SPELQQFPKD ARAIITDDGQ GLTSIDWSQI EPVTMALMAK
DHAFLAPFEA GEDLYEPIQR SAGIDRPTAK VVLLGTMYGL GIAKLARQIG HTEESAAQIR
RQMFEAMKGC ERWMRKVQNV AETYGRVVTA GGRILPVDQG YEYKAVNYAI QGSAYDVLAN
SIVEMDRRGI GDHLQLAMHD ELVVDTEVAE EVQQIMLTPP EFLITWAERV PVLRTDRADM
GSAWAKV
//
