ID A0A345NL72_9MICO Unreviewed; 297 AA.
AC A0A345NL72;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=NAD-dependent protein deacetylase 1 {ECO:0000313|EMBL:AXH95780.1};
GN ORFNames=DV701_06245 {ECO:0000313|EMBL:AXH95780.1};
OS Ornithinimicrobium avium.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC Ornithinimicrobiaceae; Ornithinimicrobium.
OX NCBI_TaxID=2283195 {ECO:0000313|EMBL:AXH95780.1, ECO:0000313|Proteomes:UP000253790};
RN [1] {ECO:0000313|EMBL:AXH95780.1, ECO:0000313|Proteomes:UP000253790}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AMA3305 {ECO:0000313|EMBL:AXH95780.1,
RC ECO:0000313|Proteomes:UP000253790};
RA Bae J.-W.;
RT "Complete genome sequencing of Ornithinimicrobium sp. AMA3305.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP031229; AXH95780.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A345NL72; -.
DR KEGG; orn:DV701_06245; -.
DR OrthoDB; 9800582at2; -.
DR Proteomes; UP000253790; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1600.10; SIR2/SIRT2 'Small Domain; 1.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR003000; Sirtuin.
DR InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
DR InterPro; IPR026590; Ssirtuin_cat_dom.
DR PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR11085:SF2; NAD-DEPENDENT PROTEIN LIPOAMIDASE SIRTUIN-4, MITOCHONDRIAL; 1.
DR Pfam; PF02146; SIR2; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR PROSITE; PS50305; SIRTUIN; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00236}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000253790};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00236}.
FT DOMAIN 10..292
FT /note="Deacetylase sirtuin-type"
FT /evidence="ECO:0000259|PROSITE:PS50305"
FT ACT_SITE 129
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT BINDING 137
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT BINDING 140
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT BINDING 189
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT BINDING 192
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
SQ SEQUENCE 297 AA; 31941 MW; 0C75EA8429881351 CRC64;
METDHLPPRT AVDEHRYAVL RDLLADGGVV VLSGAGMSTA SGIPDYRGPD GLRRVQPMQH
AEFAGSAQGR QRYWARAYTG WERFDAARPN AAHVSVADLQ AAGLVTGIIT QNVDGLHQRA
GATGVVELHG NLGRVVCLDC GETYDREQVH AWLAVANPDF DPGTVAEVRP DGDVVLPEDL
VRTFRAPRCL VCGHDRLKPD VVFFGGSVPR EVVEEAFEVT GRADMLLVLG SSLQVMSGYR
FVRRAARDGI PVGVVTRGRT RGDAEATVQL DALLDDVLPR LVEDLVDTGG AEGAATR
//
