ID A0A345P596_9GAMM Unreviewed; 161 AA.
AC A0A345P596;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Transcription elongation factor GreB {ECO:0000256|HAMAP-Rule:MF_00930};
DE AltName: Full=Transcript cleavage factor GreB {ECO:0000256|HAMAP-Rule:MF_00930};
GN Name=greB {ECO:0000256|HAMAP-Rule:MF_00930};
GN ORFNames=HYN46_06210 {ECO:0000313|EMBL:AXI02455.1};
OS Aquirhabdus parva.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Aquirhabdus.
OX NCBI_TaxID=2283318 {ECO:0000313|EMBL:AXI02455.1, ECO:0000313|Proteomes:UP000253940};
RN [1] {ECO:0000313|EMBL:AXI02455.1, ECO:0000313|Proteomes:UP000253940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYN0046 {ECO:0000313|EMBL:AXI02455.1,
RC ECO:0000313|Proteomes:UP000253940};
RA Kim M., Yi H.;
RT "Genome sequencing of Moraxellaceae gen. HYN0046.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC elongation past template-encoded arresting sites. The arresting sites
CC in DNA have the property of trapping a certain fraction of elongating
CC RNA polymerases that pass through, resulting in locked ternary
CC complexes. Cleavage of the nascent transcript by cleavage factors such
CC as GreA or GreB allows the resumption of elongation from the new
CC 3'terminus. GreB releases sequences of up to 9 nucleotides in length.
CC {ECO:0000256|HAMAP-Rule:MF_00930}.
CC -!- SIMILARITY: Belongs to the GreA/GreB family. GreB subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_00930}.
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DR EMBL; CP031222; AXI02455.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A345P596; -.
DR KEGG; mbah:HYN46_06210; -.
DR OrthoDB; 5511940at2; -.
DR Proteomes; UP000253940; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.50.30; Transcription elongation factor, GreA/GreB, C-terminal domain; 1.
DR Gene3D; 1.10.287.180; Transcription elongation factor, GreA/GreB, N-terminal domain; 1.
DR HAMAP; MF_00105; GreA_GreB; 1.
DR HAMAP; MF_00930; GreB; 1.
DR InterPro; IPR036953; GreA/GreB_C_sf.
DR InterPro; IPR018151; TF_GreA/GreB_CS.
DR InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR InterPro; IPR006358; Tscrpt_elong_fac_GreB.
DR NCBIfam; TIGR01461; greB; 1.
DR PANTHER; PTHR30437; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR PANTHER; PTHR30437:SF6; TRANSCRIPTION ELONGATION FACTOR GREB; 1.
DR Pfam; PF01272; GreA_GreB; 1.
DR Pfam; PF03449; GreA_GreB_N; 1.
DR PIRSF; PIRSF006092; GreA_GreB; 1.
DR SUPFAM; SSF54534; FKBP-like; 1.
DR SUPFAM; SSF46557; GreA transcript cleavage protein, N-terminal domain; 1.
DR PROSITE; PS00829; GREAB_1; 1.
DR PROSITE; PS00830; GREAB_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00930}; Elongation factor {ECO:0000313|EMBL:AXI02455.1};
KW Protein biosynthesis {ECO:0000313|EMBL:AXI02455.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253940};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00930};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00930}.
FT DOMAIN 5..74
FT /note="Transcription elongation factor GreA/GreB N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF03449"
FT DOMAIN 83..156
FT /note="Transcription elongation factor GreA/GreB C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01272"
SQ SEQUENCE 161 AA; 18820 MW; 43D847BE0A509674 CRC64;
MRAPYITPEG YKRLSDELDF LFRVRRPEVT RAVSEAAAMG DRSENAEYIY GKKMLREIDR
RIRFLQKRLP DLKVIDRLPD DPTKIYFGAS VELENDEGEI INIRIVGSDE FDPAQHWISI
ESPLARALIG KKVDEDVNIL LPDNRRVNYY ILNFRYDLSV T
//
