ID A0A345T1N4_9ACTN Unreviewed; 406 AA.
AC A0A345T1N4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Acetyl-CoA C-acyltransferase {ECO:0000313|EMBL:AXI79889.1};
DE EC=2.3.1.16 {ECO:0000313|EMBL:AXI79889.1};
GN ORFNames=C7M71_023280 {ECO:0000313|EMBL:AXI79889.1};
OS Peterkaempfera bronchialis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Peterkaempfera.
OX NCBI_TaxID=2126346 {ECO:0000313|EMBL:AXI79889.1, ECO:0000313|Proteomes:UP000249340};
RN [1] {ECO:0000313|Proteomes:UP000249340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 106435 {ECO:0000313|Proteomes:UP000249340};
RA Batra D., Gulvik C.A.;
RT "Streptacidiphilus bronchialis DSM 106435 chromosome.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; CP031264; AXI79889.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A345T1N4; -.
DR KEGG; stri:C7M71_023280; -.
DR OrthoDB; 3204099at2; -.
DR Proteomes; UP000249340; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:AXI79889.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000249340};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:AXI79889.1}.
FT DOMAIN 8..266
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 276..397
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 96
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 354
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 385
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 406 AA; 42899 MW; B7097059ED3C649B CRC64;
MPRTVRDVVF VDGVRTPFGK AGPKGIYHET RADDMVVACI RELLRRNPGL PAERIDEVAV
AATTQIGDQG LTIGRTAALL SGLPASVPGY AIDRMCAGAL TAVTTTAGGI AFGAYDVVVA
GGVEHMGRHP MGEGVDPNPR FVSEKLVDES ALFMGMTAEN LHDRFPHLTK ERCDAYAVAS
QEKAAKAYAN GRIQPDLVPV AVRRTSPEAG ETGWGLATAD EPMRPGTTLE NLAALKTPFR
PHGRITAGNS AGLNDGATAS LLAAEDVAVE LGLPVRMRLV SYAFAGVEPE VMGVGPVPAT
EKALAKAGLS ISDLGAFEIN EAFAVQVLAF LDHYGIADDD ERVNPYGGAI AFGHPLASSG
VRLMNQLARR FEERPDVRYG LTTMCIGFGM GGTVIWENPN FEEGAK
//
