UniProt: A0A345T2T7

Database: UniProt
Entry: A0A345T2T7_9ACTN

LinkDB:  A0A345T2T7_9ACTN 
Original site:  A0A345T2T7_9ACTN

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Ontology (4)   
   GO (4)   
Gene (1)   
   KEGG GENES (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (47)   
   InterPro (25)   
   Pfam (11)   
   PROSITE (4)   
   SMART (7)   
All databases (53)   

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ID   A0A345T2T7_9ACTN        Unreviewed;      3629 AA.
AC   A0A345T2T7;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=SDR family NAD(P)-dependent oxidoreductase {ECO:0000313|EMBL:AXI80292.1};
GN   ORFNames=C7M71_025740 {ECO:0000313|EMBL:AXI80292.1};
OS   Peterkaempfera bronchialis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Peterkaempfera.
OX   NCBI_TaxID=2126346 {ECO:0000313|EMBL:AXI80292.1, ECO:0000313|Proteomes:UP000249340};
RN   [1] {ECO:0000313|Proteomes:UP000249340}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 106435 {ECO:0000313|Proteomes:UP000249340};
RA   Batra D., Gulvik C.A.;
RT   "Streptacidiphilus bronchialis DSM 106435 chromosome.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; CP031264; AXI80292.1; -; Genomic_DNA.
DR   KEGG; stri:C7M71_025740; -.
DR   OrthoDB; 9778690at2; -.
DR   Proteomes; UP000249340; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd08952; KR_1_SDR_x; 1.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR   CDD; cd00833; PKS; 2.
DR   Gene3D; 3.30.70.3290; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 6.10.140.1830; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR041618; PKS_DE.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF00698; Acyl_transf_1; 2.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 2.
DR   Pfam; PF08659; KR; 2.
DR   Pfam; PF18369; PKS_DE; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   Pfam; PF14765; PS-DH; 1.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00827; PKS_AT; 2.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00822; PKS_KR; 2.
DR   SMART; SM00825; PKS_KS; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SMART; SM01294; PKS_PP_betabranch; 2.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00606; KS3_1; 2.
DR   PROSITE; PS52004; KS3_2; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000249340};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          33..457
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1479..1554
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1576..2002
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          3255..3330
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   3629 AA;  380188 MW;  7A031A4C3B9EB691 CRC64;
     MSDEEKILGY LRKVTADLHQ TRQRLREAEA RNQEPVAIVA MGCRFPGGVT GPEELWRLLR
     SGTDAMAEWP HDRGWDVDAC YDPEPGTPGR SYTRTGGFLD RVGDFDAGLF GISPREALGT
     DPQQRLLLEV CWEALERAGI DPLALRGSRT GVFAGTNLQD YPTLLSLSAS PEAGGVGNSP
     SVVSGRVSYT LGLEGPAVSI DTACSSSLVA LHLAAQALRA GECDLALAGG VTVMSTPGVF
     LEFSRQRGLA ADGRCKAFAD AADGTAWGEG VGVLLVERLS DARRNGHPVL AVLRASAVNQ
     DGASNGLTAP NGPSQQRVIW QALSAAGLSP ADVDAVEAHG TGTTLGDPIE AQALLATYGQ
     DRPDGSPLWL GSVKSNIGHT QAAAGVAGVM KMVLAIREGL LPQTLHVDAP SSHVDWTAGR
     VELLTEARPW PELDRPRRAG ISSFGVSGTN AHVIVEQAPP PDGSETTDAP EAAGVLPFAI
     SGRGEAALRA QAAHLRDHLR SGAGRTQRPA DVAWSLTASR PALDHRAVLI AHDPDELLRS
     LDALASGTPA AGLVRGLADT ESGPVFVFPG QGAQWVGMAV GLLDASPVFA ARVAACEAAL
     APFVDWSLAD VLRGVEGAPG LDRVDVVQPV LWAVMVSLAE LWRSFGVVPS AVVGHSQGEI
     AAAVVAGGLS LADGARVVAL RSRAIVALAG RGGMVSVALS RPDVDELLGG FAGRVSVAAV
     NGPSSVVVSG DADALDELMA LCEGREIRAR RIEVDYASHS AHVEAIREKL AQVLAPIAPV
     SGTVPFFSTV TGDWLDTSGL GAEYWYTNLR QTVQLEPAVR ALLSEGHRAF VEVSPHPVLT
     MPVQETAEAA DTGVVVTGTL RRGEGGPERF YASLAELWVR GLAVDWAPAF ADHAPRTVDL
     PTYAFQRQRY WPQPAPARVV TGDTADARFW EAVDSGDLGT LTDALALDTE ALSAVVPALS
     DYRRRAVEGA TADSWRYRIT WRPLPGGPAR SLTGSWLVVA PAQHAGNATV GAVLDALRRA
     GADPVTVPVD PESDRDGCAA ALEAALRTGD GDPRGVLSLL ALDEGPHAAR PGLPRGFAAT
     VAMVQALDGL DLRAPVWFAT RGAVATRPHH GVDSPTQSLV WGFGRVAALE QPARWGGLVD
     LPETLDVTAA DRLAGVLAGT DHEDQVAIRP TGVLARRLVR AATGGIGGAR RWTPSGTVLV
     TGGTGALGRH VARWLARSGA EHLLLVSRRG REAPGADELE AELTGLGAGV ELVACDIADR
     DALGALIAAI PAERPLTAVV HTAAVLDDGV ITSLTPERLA RVLRVKVQGA LNLDALTERH
     ELSAFVLFSS SAGTFGGPGH GNYAPGNAFL DALAEQRRAR GLPATAVAWS GWADGGMAEG
     TVGERLQRHG VRLMDPGTAV SALQRALDHD DTSLVVSDID WEVFGAELAQ GRPRRLYADL
     PDLQRVLAAT RQPDRDGAPA DGPALADRLA ELGESDRRRA VRELVRAHIA HVLNHPDPDD
     VEPTRSFREL GFDSLTAVEL RNTLGEATGL RLPATLVYDY PTPAALADHL RAELAPSTAA
     SASAPTPVPS AARTDDDPIA IVAMGCRFPA GSDSPEAFWR LLSDGVDAVA PWPDDRGWDL
     DALYDPEPGV PGRSYARTGA FLDGFADFDP GFFGISPREA LAMDPQQRLL LETSWEAFER
     AGIDPLSLKG SRTGVFAGTN YQDYSSRPIA AGQGADAHLG TGNSAAVMSG RISYTLGLEG
     PAVTVDTACS SSLVALHLAA QALRAGECDL ALAGGVTVMS TPGLYLDFSR QRGLAADGRC
     KAFADAADGT GWGEGAGMIL LERLSDARRN GHPVLALVRG SAVNQDGASN GLTAPNGPSQ
     QRVIRQALAA AGLSPAEVDA VEGHGTGTTL GDPIEAQALL ATYGQDRDED RPLWLGAVKS
     NIGHTQAAAG AAGLIKMVLA LRHGLLPRTL HVDTPSSHVD WAAGRVRLLT ENTPWPELGR
     PRRAGVSSFG ISGTNAHVIL EEAPAPEHSE SAPEPAPAQP APVVPWTVAG RTRAALRAQA
     ERLLAHVRAH PELAPRDIGL SLAATRSAFE HRAVVLGSDP AELCAGLAAL AADETAPAPT
     PGLAVGTAKG DGGLAFLFTG QGAQRTGMGR ELYDAHPAFA EAFDAVCAHL DGVREVVFGD
     DAERLDRTGA TQPALFAFEV ALYRLLESWG IEPDYLTGHS VGELAAAHVA GVLSLPDACA
     LVTARGRLMQ DLPAGGAMYS LQASEDEVAP LLAGREAEVD IAALNGPAAT VIAGDEDAAA
     EIAAHFAGLG RRTARLRVSH AFHSPRMEPM LDAFREVAGT LGYAPPRIGV VSGTTGRLAT
     AEELTSPEYW VRHARRAVRF HDAVSWLADH QVTRFLEIGP DATLTAMAQA AVDPDRALLV
     PALRKDRPET RTVLEAVARL HVHGISPDWR ALLPGARRVE LPTYAFQRDR YWLAAGPWTG
     DLEAVGIDPA GHPFLGAAVT PAGTDTVVLT GRLSLATHPW LADHAVLGRV ILPATGYLDL
     AVHAGDRTGC GHLAELTLET PLVLPESGAV QLQLVVDGAD DSGQRAFAVH SRPAGADVPW
     QRHAQGLLGP GPDRPGPAAE LTSWPPAGAV EVASDGHYQR FADGGFHYGP AFQGLGTVWR
     RGDEVFAEVA LPEQCHPDAT RFALHPALLD AAVQALLVDL PTGPEAAEGT GTGEAMLPFA
     WNGLTLHAEG ATALRVRLAP ADRPRTFSVL VTDTAGQPVA TADALSLRAV TADQLHRDPA
     DPQRTGQHTP QAALLVADWR AAVPASQPPR PETVRWILLG EGDDRVAKAL DSAGVHLESY
     ADLESLGRAV DTGMAMPEAV LVACDPRARE GRPVPEALHR LLGETHDLCR RWLTDERFTA
     SRLVLVTRGA IAATAEEGVH DPAAAALWGL VRSAQAEHPE RFQLIDLDDT DASERAMLAA
     VAAAHPQTLV RDGEPRLPGL ARVEPAATAH PDPAGPDGTG TVLVTGATGA LGALTARHLV
     VRHGVRSLLL ASRRGPAADG ADALVAELTA HGAEVRLVAC DAGDRAAVTR LLAEVPAGHP
     LTGVVHIAGV VDDGTLTSLD GSRFDRVLRP KADAAWLLHE LTADLGLSAF VLYSSVAGTF
     GSAGQANYAA ANAFLDGLAA HRRALGLPAT SLAWGAWADG SGMTASLADT DRRRMARGGM
     RPLTADQGLA LLDAALATDR PALVAMALDP GRNAVDALLR RPGAAAPRRT AEAHRPGPAA
     LAARLSGRTP EERRAVLLDL VRGQAAAALG HASPEAVEPD RLFTELGFDS LTAVELRNQL
     GTATGLRLPP TLLFDFATAD ALAAQLDRRL AEQPTATAAP AEGAAPAARS EDTLGALFRR
     ACESGRVDQG FELLQAAAEL RPTFTTPAEL PTVPEPIKLA SGTGAPPLVC FSSYVALAGV
     HQYARFASAF RGERDVWAMP TQGFGTGEPL PASLDAIARL QAESVARQLD GAPGVLLGSS
     SGGVLALAAA RHLEESGTPP TAVVLLDTYM PRADSPFLRF SQEMIGGMFD RESMFAHMDA
     DRLTAMSWYI RMIGEWEPGA LSSPVLLVRS SEPPLPADTT GPLEPHQWQT SWDRAHTVLD
     VPGNHFTMME SHARSTAAAT ADWLRTLKP
//

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