ID   A0A345XLB5_9ACTN        Unreviewed;       932 AA.
AC   A0A345XLB5;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=SDR family NAD(P)-dependent oxidoreductase {ECO:0000313|EMBL:AXK32431.1};
GN   ORFNames=DVA86_06960 {ECO:0000313|EMBL:AXK32431.1};
OS   Streptomyces armeniacus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=83291 {ECO:0000313|EMBL:AXK32431.1, ECO:0000313|Proteomes:UP000254425};
RN   [1] {ECO:0000313|EMBL:AXK32431.1, ECO:0000313|Proteomes:UP000254425}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15676 {ECO:0000313|EMBL:AXK32431.1,
RC   ECO:0000313|Proteomes:UP000254425};
RA   Labana P., Gosse J.T., Boddy C.N.;
RT   "Draft genome of the type strain Streptomyces armeniacus ATCC 15676.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; CP031320; AXK32431.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A345XLB5; -.
DR   Proteomes; UP000254425; Chromosome.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000254425}.
FT   DOMAIN          759..834
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          449..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   932 AA;  96921 MW;  7E72C8C452C223B9 CRC64;
     MQIHVRVDAP EDGDGTGRRS LTVHSRPADG EREERHAGAH PWTRHAEGFL REFAPADVPA
     PSRVPDGAWP PAQAEGVPTG DLYTRLATGG LDYGPVFQGL HTAWQQQGVT YAEVSLPEEH
     HGHADRFGIH PALLDAALHA MTLGDARRPG NEPEPAGADP AADPAPGPSV DPAAGPGVWL
     PFSWSGVTLH ARGATGLRVR MDRTESGSVS LSLTDGSGAP VASVESLAVR RIDPGRLGGA
     ADALGDALFE VDWTALPRAA GGTAEGPLAV LAPLRTGSAD GLHARLVDAL ERTGVPVASH
     PGLPDLVKAA EAEADTEAEA EAASVPGFVL LPCSAADGTA PVAAAHAATA EVLGLVQDFL
     AEDRLSASRL VVLTRGAVAA SAEGDVRDLA AAAVWGLIRS AQNENPDRLL LVDVDEADAS
     WDALPAALAT AVAHGEPQLA LREGAAHAPR LVRASPEQQS GHQTEQRTER QAEPVRLDPD
     GTVLITGGTG TLGTLLARHL VRRYGARHLL LTSRSGPDAP GAAELRAELE ESGARATITA
     CDTADRDALA RVLDAIPGGR PLTAVFHTAG VLDDATLTSL TPERLHPVLR PKVDAAWHLH
     DLTRDKDLSA FVLFSSVTAT VGSAGQANYA AANTFLDALA HHRHAQGRAA TSLAWGLWAD
     TSALTATLDE GNRSRMSRNG VVPMTADEGL ALLDASLART GGPLLVPARM DQVALRAMAG
     KGLLPVLFRG LVRMPARRAA AGVPLGQRLA GLDEAAQTEL LLQTVRTQIA AVLGHASPEA
     VDPDRAFQDL GFDSLTAVEL RNLLNSTTGL RLPATLVFDH PTPAALAAYL RGRVAPDGGP
     RTASDTLLAE LDRLEERLLG LVPDDADHAR AAARLQSLAA KLNGSPDAAA GEPSSVTDRI
     ESATADEIFE FIDKGLGRAC DMAADSPLAE RG
//