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Database: UniProt
Entry: A0A345XN83_9ACTN
LinkDB: A0A345XN83_9ACTN
Original site: A0A345XN83_9ACTN 
ID   A0A345XN83_9ACTN        Unreviewed;       559 AA.
AC   A0A345XN83;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase {ECO:0000313|EMBL:AXK33099.1};
GN   ORFNames=DVA86_10990 {ECO:0000313|EMBL:AXK33099.1};
OS   Streptomyces armeniacus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=83291 {ECO:0000313|EMBL:AXK33099.1, ECO:0000313|Proteomes:UP000254425};
RN   [1] {ECO:0000313|EMBL:AXK33099.1, ECO:0000313|Proteomes:UP000254425}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15676 {ECO:0000313|EMBL:AXK33099.1,
RC   ECO:0000313|Proteomes:UP000254425};
RA   Labana P., Gosse J.T., Boddy C.N.;
RT   "Draft genome of the type strain Streptomyces armeniacus ATCC 15676.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005879}.
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DR   EMBL; CP031320; AXK33099.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A345XN83; -.
DR   Proteomes; UP000254425; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
DR   SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:AXK33099.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000254425};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AXK33099.1}.
FT   DOMAIN          21..233
FT                   /note="Tetrapyrrole methylase"
FT                   /evidence="ECO:0000259|Pfam:PF00590"
FT   DOMAIN          292..522
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
FT   REGION          60..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          529..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        529..548
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   559 AA;  58514 MW;  D355CC2A50D62C99 CRC64;
     MSPTAAQSST TQHLYGAHGH VTFLGAGPGD PGLLTLSAVE ALARADVLVA DPQVHGIVRP
     HARAGVDTPL RGAEQPDPTG QASTAHAATG DWANIVMAAA RSGKRVVRAV VGDPGLDADA
     AQEMLACVAE GITFEVVPGV ATAVGVPAYA GVPLRDAQGT DVRFIDARTA DDRCWTESGA
     SDATLVVSVA LDSVAAAAGE LVAAGRKPDT PLSVTLAGTT TRQRTWTATL GSIAQTLKAA
     KVLPSSDGGQ PVIAVVGERS APAHREQLAW FESKPLFGWQ VLVPRTKEQA ASLSDQLRSY
     GAVPAEVPTI AVEPPRTPQQ MERAVKGLVT GRYEWIAFTS VNAVKAVREK FEEYGLDARA
     FAGIKVAAVG EQTAAALVEF GVKPDLVPSG EQSAAGLLED WPPYDPVFDP IDRVFLPRAD
     IATETLVAGL IELGWEVDDV TAYRTVRASP PPAETREAIK GGGFDAVLFT SSSTVRNLVG
     IAGKPHNVTI IACIGPATAK TAEEHGLRVD VLSPEPSVHK LAEALADYGQ KRRSEAAEAG
     EPVKRPSEKR PTRRRARTS
//
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