ID A0A346PNF9_9EURY Unreviewed; 550 AA.
AC A0A346PNF9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=NADH-ubiquinone oxidoreductase chain C/D {ECO:0000313|EMBL:AXR81054.1};
GN ORFNames=AArcMg_1037 {ECO:0000313|EMBL:AXR81054.1};
OS Natrarchaeobaculum sulfurireducens.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrarchaeobaculum.
OX NCBI_TaxID=2044521 {ECO:0000313|EMBL:AXR81054.1, ECO:0000313|Proteomes:UP000258613};
RN [1] {ECO:0000313|Proteomes:UP000258613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AArc-Mg {ECO:0000313|Proteomes:UP000258613};
RA Sorokin D.Y., Kublanov I.V., Roman P., Sinninghe Damste J.S.,
RA Golyshin P.N., Rojo D., Ciordia S., Mena M.D.C., Ferrer M., Messina E.,
RA Smedile F., La Spada G., La Cono V., Yakimov M.M.;
RT "Phenotypic and genomic properties of facultatively anaerobic sulfur-
RT reducing natronoarchaea from hypersaline soda lakes.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124;
CC Evidence={ECO:0000256|ARBA:ARBA00000100};
CC -!- SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD,
CC E, F, and G constitute the peripheral sector of the complex.
CC {ECO:0000256|ARBA:ARBA00038617}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the complex I 49 kDa
CC subunit family. {ECO:0000256|ARBA:ARBA00010019}.
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DR EMBL; CP027033; AXR81054.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A346PNF9; -.
DR KEGG; nag:AArcMg_1037; -.
DR OrthoDB; 43567at2157; -.
DR Proteomes; UP000258613; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1.
DR Gene3D; 3.30.460.80; NADH:ubiquinone oxidoreductase, 30kDa subunit; 1.
DR HAMAP; MF_01358; NDH1_NuoD; 1.
DR InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR InterPro; IPR037232; NADH_quin_OxRdtase_su_C/D-like.
DR InterPro; IPR001268; NADH_UbQ_OxRdtase_30kDa_su.
DR InterPro; IPR020396; NADH_UbQ_OxRdtase_CS.
DR InterPro; IPR022885; NDH1_su_D/H.
DR InterPro; IPR029014; NiFe-Hase_large.
DR PANTHER; PTHR11993:SF10; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11993; NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT; 1.
DR Pfam; PF00329; Complex1_30kDa; 1.
DR Pfam; PF00346; Complex1_49kDa; 1.
DR SUPFAM; SSF56762; HydB/Nqo4-like; 1.
DR SUPFAM; SSF143243; Nqo5-like; 1.
DR PROSITE; PS00542; COMPLEX1_30K; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Reference proteome {ECO:0000313|Proteomes:UP000258613};
KW Ubiquinone {ECO:0000313|EMBL:AXR81054.1}.
FT DOMAIN 37..155
FT /note="NADH:ubiquinone oxidoreductase 30kDa subunit"
FT /evidence="ECO:0000259|Pfam:PF00329"
FT DOMAIN 300..550
FT /note="NADH-quinone oxidoreductase subunit D"
FT /evidence="ECO:0000259|Pfam:PF00346"
SQ SEQUENCE 550 AA; 62409 MW; EC79FBE438A86C35 CRC64;
MSTGVEETSD VEREDQLEAL LGDRVLARDE HLNAPGVVVN PGDVQDVLFT LRDEAGYDHC
SCVTAQQYED RYETIYHLKK FADPTDEVSV VVPTPLDAPV SQSAEPVYRT ADWHEREAYD
LVGIEYDDHP DLRRILLPET WQGHPLGGDY DQDKPQVVTL SEHANPLAPD HRDSEGDTMF
LNVGPHHPAT HGVLHVKTVL DGETVVDVDP DIGYLHRCEE QMCQQGTYRH QIMPYPDRWD
YVSSGLLNEW AYARAIEDMA DIEVPEYAQI IRTMGSELCR IASHMLALGT FALDVYGEFT
ATFMYTFRDR EIIQDLLEDL TGQRMMFNYF RVGGVAWDLP EPREEFFAQA RDFLDELPSK
VDEYNDLITT NEIFQLRCAD TGILEPEVAK QYGCTGPVAR GSGIDYDLRR DDPYGYYDEL
DWDVVTMDGC DNYSRVLVRM QEVEESAKIV EQCLDVLESW PEDERDIQAN VPRTLKPDAD
AEIYRAVEAA KGELGIYMRS DGTDKPARFK IRSPCFSNLQ ALGEMTEGEY IPDLVASLGS
LDIVLGEVDR
//
