ID A0A346PTF6_9EURY Unreviewed; 436 AA.
AC A0A346PTF6; A0A346PCJ2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Glutamate dehydrogenase {ECO:0000256|PIRNR:PIRNR000185};
GN ORFNames=AArc1_0896 {ECO:0000313|EMBL:AXR77237.1}, AArcMg_2811
GN {ECO:0000313|EMBL:AXR82801.1};
OS Natrarchaeobaculum sulfurireducens.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrarchaeobaculum.
OX NCBI_TaxID=2044521 {ECO:0000313|EMBL:AXR82801.1, ECO:0000313|Proteomes:UP000258613};
RN [1] {ECO:0000313|Proteomes:UP000258707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AArc1 {ECO:0000313|Proteomes:UP000258707};
RA Sorokin D.Y., Kublanov I.V., Roman P., Sinninghe Damste J.S.,
RA Golyshin P.N., Rojo D., Ciordia S., Mena Md.C., Ferrer M., Messina E.,
RA Smedile F., La Spada G., La Cono V., Yakimov M.M.;
RT "Phenotypic and genomic properties of facultatively anaerobic sulfur-
RT reducing natronoarchaea from hypersaline soda lakes.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000258613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AArc-Mg {ECO:0000313|Proteomes:UP000258613};
RA Sorokin D.Y., Kublanov I.V., Roman P., Sinninghe Damste J.S.,
RA Golyshin P.N., Rojo D., Ciordia S., Mena M.D.C., Ferrer M., Messina E.,
RA Smedile F., La Spada G., La Cono V., Yakimov M.M.;
RT "Phenotypic and genomic properties of facultatively anaerobic sulfur-
RT reducing natronoarchaea from hypersaline soda lakes.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AXR82801.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AArc-Mg {ECO:0000313|EMBL:AXR82801.1}, and AArc1
RC {ECO:0000313|EMBL:AXR77237.1};
RX PubMed=31166158;
RA Sorokin D.Y., Yakimov M., Messina E., Merkel A.Y., Bale N.J.,
RA Sinninghe Damste J.S.;
RT "Natronolimnobius sulfurireducens sp. nov. and Halalkaliarchaeum
RT desulfuricum gen. nov., sp. nov., the first sulfur-respiring alkaliphilic
RT haloarchaea from hypersaline alkaline lakes.";
RL Int. J. Syst. Evol. Microbiol. 69:2662-2673(2019).
CC -!- SUBUNIT: Homohexamer. {ECO:0000256|ARBA:ARBA00011643}.
CC -!- SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
CC {ECO:0000256|ARBA:ARBA00006382, ECO:0000256|PIRNR:PIRNR000185,
CC ECO:0000256|RuleBase:RU004417}.
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DR EMBL; CP024047; AXR77237.1; -; Genomic_DNA.
DR EMBL; CP027033; AXR82801.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A346PTF6; -.
DR KEGG; nag:AArcMg_2811; -.
DR KEGG; nan:AArc1_0896; -.
DR OrthoDB; 6425at2157; -.
DR Proteomes; UP000258613; Chromosome.
DR Proteomes; UP000258707; Chromosome.
DR GO; GO:0016639; F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR CDD; cd01076; NAD_bind_1_Glu_DH; 1.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR006095; Glu/Leu/Phe/Val/Trp_DH.
DR InterPro; IPR006096; Glu/Leu/Phe/Val/Trp_DH_C.
DR InterPro; IPR006097; Glu/Leu/Phe/Val/Trp_DH_dimer.
DR InterPro; IPR033524; Glu/Leu/Phe/Val_DH_AS.
DR InterPro; IPR014362; Glu_DH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR033922; NAD_bind_Glu_DH.
DR NCBIfam; NF041398; GluDhGdhB_Halo; 1.
DR PANTHER; PTHR11606; GLUTAMATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11606:SF13; GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL; 1.
DR Pfam; PF00208; ELFV_dehydrog; 1.
DR Pfam; PF02812; ELFV_dehydrog_N; 1.
DR PIRSF; PIRSF000185; Glu_DH; 1.
DR PRINTS; PR00082; GLFDHDRGNASE.
DR SMART; SM00839; ELFV_dehydrog; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00074; GLFV_DEHYDROGENASE; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000185};
KW Reference proteome {ECO:0000313|Proteomes:UP000258613}.
FT DOMAIN 199..433
FT /note="Glutamate/phenylalanine/leucine/valine/L-tryptophan
FT dehydrogenase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00839"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 122
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000185-1"
FT SITE 162
FT /note="Important for catalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000185-3"
SQ SEQUENCE 436 AA; 47389 MW; 03135690890AFC54 CRC64;
MATRREYQPV SDEVPTESAD ESALETARRQ LARAAAALEI DDAIHERLEH PASVHEVTVP
LERDDGTVDV FTGFRAQHDS VRGPYKGGLR YHPEVSRDEC VGLAMWMTWK CAVMDLPFGG
AKGGIVVDPK SLSTDEKERL TRRFTQELRE VIGPTVDIPA PDMGTDPQTM AWLMDAYSMQ
EGETTPGVVT GKPPAVGGSY GREEAPGRSV AIVTRETCEY YDRPLEDVTV AVQGFGSVGA
NAARLLEEWG ATVVATSDVN GAIYDPDGLD VAGIPSHDEE PEAVTSYAAE RDDLVTLSND
DLLELDVDVL VPAAVGNVIT ADNAGEIQAD LVVEGANGPT TTAADAILEE RDVTVIPDIL
ANAGGVTVSY FEWLQDINRR KWSPERVQEE LETEMQNAWN AVRTAVEDRD VTWRDGAYVV
ALSRIADAHD SRGLWP
//
