ID   A0A346RV20_9REOV        Unreviewed;       532 AA.
AC   A0A346RV20;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Outer capsid protein VP5 {ECO:0000256|ARBA:ARBA00015353};
GN   Name=VP5 {ECO:0000313|EMBL:AXS78003.1};
OS   Guangxi orbivirus.
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Orbivirus.
OX   NCBI_TaxID=2306813 {ECO:0000313|EMBL:AXS78003.1, ECO:0000313|Proteomes:UP000288985};
RN   [1] {ECO:0000313|EMBL:AXS78003.1, ECO:0000313|Proteomes:UP000288985}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=V172/GX/2015 {ECO:0000313|EMBL:AXS78003.1,
RC   ECO:0000313|Proteomes:UP000288985};
RA   Yang H., Li Z., Zhang Y., Gao L., Xie J., Liao D., Wang J., Li H.;
RT   "Isolation and Genomic Characterization of Guangxi Orbivirus: A New
RT   Orbivirus Species Isolated From Cattle in China.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: VP5 protein is one of the two proteins (with VP2) which
CC       constitute the virus particle outer capsid. Acts as a membrane
CC       permeabilization protein that mediates release of viral particles from
CC       endosomal compartments into the cytoplasm. Permeabilization activity is
CC       probably negatively regulated by VP2 and is triggered by endosomal
CC       degradation of VP2 and exposure to low pH.
CC       {ECO:0000256|ARBA:ARBA00024835}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP5 family.
CC       {ECO:0000256|ARBA:ARBA00007624}.
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DR   EMBL; MG020129; AXS78003.1; -; Genomic_RNA.
DR   Proteomes; UP000288985; Genome.
DR   GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR000145; Capsid_VP5_Orbivir.
DR   Pfam; PF00901; Orbi_VP5; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000288985}.
SQ   SEQUENCE   532 AA;  58938 MW;  857DB60A983916BF CRC64;
     MGKFTNALSR IGRGFKNVVT SETTRKIVSN VGNVAMRALE SEVGQKVVAG VVQGIAEASI
     SDVDTGAAVK RAVIGNVLGI HDPPIDPLNP GEQLLANRIR EINGEMKAIE SFDRHSAAVQ
     RKLNTSIEKL NKVVKNTAEA TLEEEDQVGN LDVAMRSMLE ITEHETKNLQ MLHEALGKEA
     RLRNREENKL IEAMKLNYQA MANTVKAEKD AIMEEAIEQI VDIGGEIAEH LAAEAPLVGE
     SIAAGMATAR GVQQMYKLNK TISRISGVPV PHIELPAISP VAVDTLFNSE AINESTLQKV
     INSKLRHIEE IKKEVVHLNE VLNTELKKKS VEENRKVGVP ENTVHHVVRS QFHVPRTKRP
     GVHIYTAPYD SEYILILLFV SPYSIHRSFM VCVDLAIDFV YYNDIAHGGT RVHKGPKGAS
     GMLNFRNGCK DFFKESASHA GSTRMHSERL LRSAGGEPMY ITSMQYPYSF VQTRKHAEVF
     CKNPEVQKHI LRGPLNMQRT SVLNAIFHGV TLVSMAKSRS VQQGTRVQRP RS
//