ID A0A346Y429_9ACTN Unreviewed; 133 AA.
AC A0A346Y429;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Ribonuclease VapC {ECO:0000256|HAMAP-Rule:MF_00265};
DE Short=RNase VapC {ECO:0000256|HAMAP-Rule:MF_00265};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00265};
DE AltName: Full=Toxin VapC {ECO:0000256|HAMAP-Rule:MF_00265};
GN Name=vapC {ECO:0000256|HAMAP-Rule:MF_00265};
GN ORFNames=DVS28_a4565 {ECO:0000313|EMBL:AXV09226.1};
OS Euzebya pacifica.
OC Bacteria; Actinomycetota; Nitriliruptoria; Euzebyales.
OX NCBI_TaxID=1608957 {ECO:0000313|EMBL:AXV09226.1, ECO:0000313|Proteomes:UP000264006};
RN [1] {ECO:0000313|EMBL:AXV09226.1, ECO:0000313|Proteomes:UP000264006}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY32-46 {ECO:0000313|EMBL:AXV09226.1,
RC ECO:0000313|Proteomes:UP000264006};
RA Xu L., Wu Y.-H., Xu X.-W.;
RT "Complete genome sequence of Euzebya sp. DY32-46 isolated from seawater of
RT Pacific Ocean.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Toxic component of a toxin-antitoxin (TA) system. An RNase.
CC {ECO:0000256|HAMAP-Rule:MF_00265}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00265};
CC -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC {ECO:0000256|ARBA:ARBA00038093, ECO:0000256|HAMAP-Rule:MF_00265}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP031165; AXV09226.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A346Y429; -.
DR KEGG; euz:DVS28_a4565; -.
DR OrthoDB; 4377304at2; -.
DR Proteomes; UP000264006; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd09873; PIN_Pae0151-like; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR HAMAP; MF_00265; VapC_Nob1; 1.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR044153; PIN_Pae0151-like.
DR InterPro; IPR022907; VapC_family.
DR PANTHER; PTHR35901:SF1; EXONUCLEASE VAPC9; 1.
DR PANTHER; PTHR35901; RIBONUCLEASE VAPC3; 1.
DR Pfam; PF01850; PIN; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00265};
KW Magnesium {ECO:0000256|HAMAP-Rule:MF_00265};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00265};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00265};
KW Reference proteome {ECO:0000313|Proteomes:UP000264006};
KW Toxin {ECO:0000256|HAMAP-Rule:MF_00265};
KW Toxin-antitoxin system {ECO:0000256|ARBA:ARBA00022649, ECO:0000256|HAMAP-
KW Rule:MF_00265}.
FT DOMAIN 4..121
FT /note="PIN"
FT /evidence="ECO:0000259|Pfam:PF01850"
FT BINDING 6
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00265"
FT BINDING 96
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00265"
SQ SEQUENCE 133 AA; 14185 MW; A433154D7CC9DDFD CRC64;
MTAVPDASVV VAALVDGGPV GAWAESVLAD NQLAAPHLLL VEVANILRRT SLAAQLSQDA
ADLAHADLLD LRVALFDYET VADRIWQLRH NVTTYDAWYV AVAERLDAPL VTLDRRLSTA
AGPTCTFVLP PAA
//
