ID A0A347W4S0_9HELI Unreviewed; 384 AA.
AC A0A347W4S0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=UDP-N-acetylglucosamine 2-epimerase (Hydrolyzing) {ECO:0000313|EMBL:TLD92383.1};
DE EC=3.2.1.183 {ECO:0000313|EMBL:TLD92383.1};
GN Name=neuC {ECO:0000313|EMBL:TLD92383.1};
GN ORFNames=DCO61_08000 {ECO:0000313|EMBL:MWV69942.1}, LS64_010345
GN {ECO:0000313|EMBL:TLD92383.1};
OS Helicobacter saguini.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1548018 {ECO:0000313|EMBL:TLD92383.1, ECO:0000313|Proteomes:UP000029714};
RN [1] {ECO:0000313|EMBL:TLD92383.1, ECO:0000313|Proteomes:UP000029714}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 97-6194 {ECO:0000313|EMBL:TLD92383.1,
RC ECO:0000313|Proteomes:UP000029714};
RX PubMed=25428971;
RA Sheh A., Shen Z., Fox J.G.;
RT "Draft genome sequences of eight enterohepatic helicobacter species
RT isolated from both laboratory and wild rodents.";
RL Genome Announc. 2:e01218-e01214(2014).
RN [2] {ECO:0000313|EMBL:TLD92383.1, ECO:0000313|Proteomes:UP000029714}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 97-6194 {ECO:0000313|EMBL:TLD92383.1,
RC ECO:0000313|Proteomes:UP000029714};
RX PubMed=27245408; DOI=.1128/IAI.00235-16;
RA Shen Z., Mannion A., Whary M.T., Muthupalani S., Sheh A., Feng Y., Gong G.,
RA Vandamme P., Holcombe H.R., Paster B.J., Fox J.G.;
RT "Helicobacter saguini, a Novel Helicobacter Isolated from Cotton-Top
RT Tamarins with Ulcerative Colitis, Has Proinflammatory Properties and
RT Induces Typhlocolitis and Dysplasia in Gnotobiotic IL-10-/- Mice.";
RL Infect. Immun. 84:2307-2316(2016).
RN [3] {ECO:0000313|EMBL:TLD92383.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MIT 97-6194 {ECO:0000313|EMBL:TLD92383.1};
RA Sheh A., Shen Z., Mannion A.J., Fox J.G.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:MWV69942.1, ECO:0000313|Proteomes:UP000477070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16-048 {ECO:0000313|EMBL:MWV69942.1}, and 16-048 (F4)
RC {ECO:0000313|Proteomes:UP000477070};
RA Mannion A., Shen Z., Fox J.G.;
RT "Multi-Generational Helicobacter saguini Isolates.";
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TLD92383.1}.
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DR EMBL; QBIU01000001; MWV69942.1; -; Genomic_DNA.
DR EMBL; JRMP02000020; TLD92383.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A347W4S0; -.
DR STRING; 1548018.LS64_07430; -.
DR OrthoDB; 9803238at2; -.
DR Proteomes; UP000029714; Unassembled WGS sequence.
DR Proteomes; UP000477070; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:InterPro.
DR GO; GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR020004; UDP-GlcNAc_Epase.
DR InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR InterPro; IPR029767; WecB-like.
DR NCBIfam; TIGR03568; NeuC_NnaA; 1.
DR PANTHER; PTHR43174; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR PANTHER; PTHR43174:SF3; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR Pfam; PF02350; Epimerase_2; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000313|EMBL:TLD92383.1};
KW Hydrolase {ECO:0000313|EMBL:TLD92383.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000029714}.
FT DOMAIN 29..364
FT /note="UDP-N-acetylglucosamine 2-epimerase"
FT /evidence="ECO:0000259|Pfam:PF02350"
SQ SEQUENCE 384 AA; 43466 MW; 38F9E32264BAC6D0 CRC64;
MTTLSKRKKI VFVSGTRADF SKMKSLMKKV EDSKDFEAII FATGMHLSKN FGLTVREIEK
SGFQNIYRFI NHDKYYQMDL ALSSTIDGFS KFINEYEPDL IVVHGDRIEP LAAAIVGALN
NILVAHIEGG EVSGTIDDSL RHSISKLAHI HLVNDSNAQK RLLQLGENKD SIFIIGSPDL
DILAHNDISL DAAKKYYDID FSDYAIAIFH PVTTELDSLE SQINEFVTAL IESKQNYIVI
YPNNDLGFNI ILNAYKRLEN NAHFKLFPSL RFEYFITLLK HCKFIIGNSS CILKEAVFFG
VHGINVGTRQ NNRAGINNKN ITNVGAKSKE ILNAIKNIES IESKHTDSAH NTQNTERSDT
RFYNLLEQGN IFNISKQKTF RDIF
//
