ID   A0A348AKV1_9FIRM        Unreviewed;       336 AA.
AC   A0A348AKV1;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000313|EMBL:BBB91699.1};
DE            EC=4.2.1.46 {ECO:0000313|EMBL:BBB91699.1};
GN   Name=strE_2 {ECO:0000313|EMBL:BBB91699.1};
GN   ORFNames=MAMMFC1_02383 {ECO:0000313|EMBL:BBB91699.1};
OS   Methylomusa anaerophila.
OC   Bacteria; Bacillota; Negativicutes; Selenomonadales; Sporomusaceae;
OC   Methylomusa.
OX   NCBI_TaxID=1930071 {ECO:0000313|EMBL:BBB91699.1, ECO:0000313|Proteomes:UP000276437};
RN   [1] {ECO:0000313|EMBL:BBB91699.1, ECO:0000313|Proteomes:UP000276437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MMFC1 {ECO:0000313|EMBL:BBB91699.1,
RC   ECO:0000313|Proteomes:UP000276437};
RX   PubMed=29458677; DOI=10.1099/ijsem.0.002635;
RA   Amano N., Yamamuro A., Miyahara M., Kouzuma A., Abe T., Watanabe K.;
RT   "Methylomusa anaerophila gen. nov., sp. nov., an anaerobic methanol-
RT   utilizing bacterium isolated from a microbial fuel cell.";
RL   Int. J. Syst. Evol. Microbiol. 68:1118-1122(2018).
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DR   EMBL; AP018449; BBB91699.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A348AKV1; -.
DR   KEGG; mana:MAMMFC1_02383; -.
DR   OrthoDB; 9766450at2; -.
DR   Proteomes; UP000276437; Chromosome.
DR   GO; GO:0016831; F:carboxy-lyase activity; IEA:InterPro.
DR   GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   CDD; cd05257; Arna_like_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR045869; Arna-like_SDR_e.
DR   InterPro; IPR026390; LegB-like.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR04180; EDH_00030; 1.
DR   PANTHER; PTHR43000:SF2; BLR5989 PROTEIN; 1.
DR   PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   PRINTS; PR01713; NUCEPIMERASE.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:BBB91699.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276437}.
FT   DOMAIN          9..310
FT                   /note="NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16363"
SQ   SEQUENCE   336 AA;  36860 MW;  C800D189953AC40B CRC64;
     MKLQGNKILI TGADGFIGSH LTEELIRQGC DVRAFVMYNS FNSWGWLDAS PVSIKSELDV
     FAGDIRDPHG VKAAMKGCQV VLHLAALIAI PYSYHSPDTY VDTNIKGTLN IVQAAKELGI
     NKVVHTSTSE VYGSAQFVPI TEDHPLQGQS PYSASKIGAD QMAMSFYRSF NVPVAIIRPF
     NTYGPRQSAR AVIPTIITQL ANGKSDIRLG ATNPTRDFNY VKDTVRGFIA IAEADQAIGE
     IINIGSNYEI SVGEVAALIS QIMGVNMTIE TDNQRLRPEK SEVERLWADN AKARTLLGWE
     PVYGGKEGLK RGLKETVEWF TDPNNLNSYK AGVYNI
//