ID A0A348AVR9_9VIRU Unreviewed; 4312 AA.
AC A0A348AVR9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Genome polyprotein {ECO:0008006|Google:ProtNLM};
OS Osedax japonicus RNA virus 1.
OC Viruses; Riboviria.
OX NCBI_TaxID=2079458 {ECO:0000313|EMBL:BBC62177.1, ECO:0000313|Proteomes:UP000289604};
RN [1] {ECO:0000313|EMBL:BBC62177.1, ECO:0000313|Proteomes:UP000289604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OjRV1 {ECO:0000313|EMBL:BBC62177.1};
RX PubMed=30318497; DOI=10.1264/jsme2.ME18089;
RA Urayama S., Takaki Y., Nunoura T., Miyamoto N.;
RT "Complete Genome Sequence of a Novel RNA Virus Identified from a Deep-Sea
RT Animal, Osedax japonicus.";
RL Microbes Environ. 33:446-449(2018).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LC367326; BBC62177.1; -; Genomic_RNA.
DR Proteomes; UP000289604; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008174; F:mRNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR InterPro; IPR002588; Alphavirus-like_MT_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001788; RNA-dep_RNA_pol_alsuvir.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00978; RdRP_2; 1.
DR Pfam; PF01443; Viral_helicase1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS51743; ALPHAVIRUS_MT; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000289604};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT TRANSMEM 1103..1120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1217..1240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 320..528
FT /note="Alphavirus-like MT"
FT /evidence="ECO:0000259|PROSITE:PS51743"
FT DOMAIN 4065..4180
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 99..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2007..2094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2049..2069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2072..2087
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4312 AA; 475533 MW; 072FD3259FA31EBA CRC64;
MTTKQQTATA FGLSSAAHWR RFRQPIEKRL QGTVPVRVVQ KAVNVDAPEG IMTAPVAEKS
VSWAGELCSY SVIDGKHCDV GKEEAPVDDK EQDAEGMEVA AKSTTAKCSA ARVTNKHRRD
EETVRRIDDE PIDRSPRKGR SRVKRNTSRR QGSTIVGGAL ADKTAPGKRN GVGQTAAEDV
SGSDTFMSAE GNDSATQTGE STESSGTGTS NVEGGDDAEP NTEDHSNQQE TPPEDDTHRD
EENVENNVST EGPSNYMMAE DESALPELTV PTDGPEFVVK KHENANKRVT PTTLYIRYND
DNKRTAIEDL FSTKYGKEKL QFSTDNNAHA TCAAARKMAN VYITKEIKAM VGKVRPILVG
GNPVPYMSAG VATHCTMPLA TAKDVARHKH IHEYVCERAK DGEPEAEEFV KSIGVLQTKL
NAEKHKLYET EHMCYNGAQA CSYKSNVAVL IETVYDMPRD TTMRRLAAQG VEIVYYTMFV
PLFAAEGATI GYHRLLDAEW SLGDARERVG DHSAPNIEND FSDRLAKVKL GDEVTDRGTI
RYHISSVPYV HEINVMFPWM TDANYEFVGE SGKKIYVSVE VVQDVDKFVT FKATMNSYKA
AADRPEFLTY ECDDDTIIAP MASLTNGKVG VVKAIALPQA MISFVRSKTT HCITKGVFNT
GTIVADAISM CNSIVIKNSS ISTTDDKLIR DINSVALALV RIIKENYRSS EELLATGTNR
MSAYTRTVVC STIFMAGLVT THKIAKMATL IGSKMAPALS GEINAVMKYM TMVADATYIM
MGGAKLMESV DLNLDRLFDR SMQPILVNKR NRISFSSANR AITKGALPAT TIRPLGIISG
AGVNISGSGY GYAWFVEAIK SVISRFSFGQ GIGRHVHKIL IRLIQAMPAP MLGAAIKALV
GVFSEDVLAH ALESRKKYVS EREIEVKGSK KELSLWLPEG TKKRSTLAEV VAMGCSTQLV
DNQVLDTLTR NDTHPLSAGE MITLVNYMQD DNQSSAQCEE VLTKIKMLLH GTKIGLAILT
KDAPGAVLVA DPSTDAGSLC YIIPLWLEQD GSIYYLMEGE EPADLITGSA TLALSAYDFE
LVCSPLTKVD IWWKRLKATI SKGLAVMALS SLALFCVLLA REHYLALAML NIPAAVAASA
TSKIVEVMTN MLNSTAGMRH AASSQVAQWF AMLSMYSVRV VGRVSGRGVV SMGWYEIFIT
GPLSFITTNI KTIYKWIVYN IAPVAAAATL ASVGLAYSLF PENDDSTQSK DDTWEKKTSN
GLDLGDNDFG NAHAKADVNA EDEAIEVEVD LEKPSLESQK LLADILAQTA MRSAITLDSA
EYGGEDFYSE GTPVVVNSPY VLTDSKDSPL VVSTCETNYF YTNDDTCVGK ATLRLKHAQG
NCFFDCFKGL DNDASAMKMR QTILEKTKAC DLFSGSVALK NVEDGVSLSE AAAFAYLTNI
TIIVHGVPVL SGSGKDETII APKGAEEAVL VRPIVLNHAT EAHKERGIVL NTHHIRIHNN
HFAAYLHKYD GVWRSLVTVG YDSAKYRLHL SSDLSVNPRA MGADIAYFAA IRTWAYKMIA
LVGEEAKHIK CQGGTLTAPF IEFVKTHPWL SSTVALPLLW KAIQYQMPGV TDVLRVIYSG
MHVALQMGYH GVRSMITRAE TFDCVDIALS KAFGELKYSR ADMQEYLRVK DESDGEPYVG
SWENSSRSGH SAAMLQCVAS RYGVVLVITQ WKKPTSYFMP EGIYVQEKDN LELRNKLRGA
VVELKRSGNH VTFSSIRYKT ELADRDAELG GVGAWDLRLP TSAVEGYVKS LAAALKKTAL
ISMAQFSVQQ LVCVFDPAVR VHITSRTLQR VLKSCAGFLD NESTNDRTKL MRLAPLTVLN
VAAAAGIHTS YITALPALMI INAALPALLD LLEYEKATSE QDHNVDNTVT TAAMKALSES
VRNIVANAFK ISASMLNQYP RIPAAIMLSA KVGAAAKLLQ VQGVLSIGGL WTAAACIAKC
ATVVAQIKAL DSCEEIVIAT IAPTDAKTSS ETESALNEVD GHSTKPGGIS SGEKAPQNGD
GDAHEVNTAT MMPSYSTKTS GSTITGGGLE DVESSEKNEE WPDEQPERTI VTPDVPSYED
VKSASYRIQV LDRNTRSSEV GTSSSVGHKI FGLFTRSHTD PGRTSRDGFK TISELTEYMR
HHMPNCYLEL PKYYNAESDP RYWYVDNEGK VFSLARVQDG KVLARLVGMV VEERMLIDGA
VSHALLVTPI ELDNDEAKPY EKEEEQSLFT PNVSLDYHDL VVDEHGYICD GTALMHMRQQ
NVEVTTGVQA AARAVSTMEN RRRRYNEVGR ADATEAKKLN QQQPIDSVSL TFNDHKNVFA
EFEAASTQEH SYATFKLKLR KGGITEMVKK AVITIGEKAA NIGGGLKNSS IPALRRKSEA
NDPKENIHAT IDDMAQDGRL ADPSAPRTVA ELAHVRLVAP KKADAAHKGP EVRGGSLTHK
REAVVNLPLL RDHANVMQAM KLDIHAVSEA GYRIIHNHKN LITVNLGHPG YLMYGNMYLL
PHNTLVKGPL AKLAHNMKTM CCDEFNLATL SLPVTRAYLV IPIVNQLPLH RFLSLVETLT
LSMQKVQASL RSMIWQHANN QGNRSNTEKD EELLIPVATD HVKPDSYYFS TKAMAISAGA
HAQGKVYMHK SLDFPHEAVI LMSMANMERA VTDFSTPLFS LQGIPGSGKT YCIVSNADHR
DAVVGCRKES LLGQQFDCSY VKTLASVIIN PPAQPLRPDI LYIDEYLAVH GGEILIVIAL
LKPRLATVLI GDVQQMSYYS STGIPVYYND LDIPKHNSYA LPISATLPAE IIAAFPNKYP
GMDIHTTNDT KLTLEVQPYS VSSARAQSLH VAYGLSTALM LKKTFGERAM TISASQGMRS
ESVVINIPHN SINMFNAVES AATWVAVSRT TKEIIVNTGI IADHVGTTLK NAQESDVSRI
LVPQSAWREQ HEKIDRMINN IRNDAYVRNL QQQEYDTSRF HCWMVVALQI SKDTLPLAFT
QDQLTVLNDA WHDEKVDNPM ACLSRLAMMA YGIDLEMAAG ALNDGEGTFY YRSRVSETDY
HWGCSPTFES TKWHFGLARS VLKVFERMNV RDDGANECAR ARTVGIDRIN LRTTIFPEEN
ETVLTRLSPG MLSKCINNLI QVRKYDDSYK NSLVLLSSKS WSVRATAKPV LERRHLYADM
VGSSIVTSFY FSHRPDWSSM LENSPGDATR WAGTLKPFAD QLRRCHVAKK HRDIYRKLYH
FMENAYPGRR YIELCAAPGS LYKACKERGV LANIEFVQHA FAGASPMYTD VNMQHISTCR
AKLFESGCKC LELLGAKVAL IDIAMPRTGR VDDQYAFNAY AFEAVCRKLD STNHAAAVKT
FACRSLSIFM STLTRTDVSL ARSAGSSDCG VEVFVLFAAP SRSSVTTIGI QLSAIVAMMM
THAPIANADA SEKRSYDPDS LFGSYCVPPE QASLLPAPTS PISHLIPHGQ DPGLGRPRYV
KCVVKIYAEE TRRTGLQFYN ADGTRRTPFG VTRNSVAAKL RLWRMKIVLS INGNSAMPRT
SAFDVRDASV SIIECLVEEG EANTYISNHD DPARRRHIRV PARSSMVGMM HDDRIVCSVV
TCDCTSHIPM PPSAYKLVPS ALALAIHVQN FSDSHNDFFN NIIPYIDGSK TFVVRSKLNV
SLKSWITPGS CESGYDGGLH SIQYYLTTNT GTMAFCSLKR PPSSTERRCS CGTSRNRFRY
GSGGYIFSHS KSMKPAAVAT NEYEHASDMG LLADDDETTL ATALKEASYE DILRFASWRI
SKLRESRRHV RQYPKIRVGE VMSSEPPSLP SSSVFNINFW MSIHYPANVW RYAGPRDDDA
LESVHNVHIG FTKLRIKAEA LCIPQTSKLY HVPRVRSGAK CSLAVNLRTL NEAYTKRNGS
AYTFRHMESN SVIAANLITN LLRHMCKPNV NELLAQYRRD PIGPSTHNVR EWVRFTEPEK
LRRLGKKMEG IDDFGEVDLS KMNFEIKSAV KIKPGTAHIT TNPQPQTITA AHAAMTAIFS
GLMEQVWDRL VAILNDNIFI PYAHDASAFN AFLTHHLRNY TTSEYYFHEI DISAYDKSQD
YATATAIMAL FELLGVTPEV MDAMDISLRT IRCRNATVGI SFSINSMMRS GAFYTLIGNT
MVSLMVTACA YGESFRKVIC ASFIGDDSLI ASTSKMPMKV PVILENRCGM EAKTLLTSVS
ERVSPIPPMF CSGYIIYDPA LHTYQRLCDP IRRMFKLGIP VHPKALSKQD RYRSLKEEVD
SWAFCGLWDS LASSSDRRLG VSGTKFVMEQ LRSLTHNINN YSYLYGPEEW SV
//
