ID A0A348HGB6_9GAMM Unreviewed; 409 AA.
AC A0A348HGB6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Thiamine biosynthesis enzyme ThiH {ECO:0000313|EMBL:BBG30668.1};
GN ORFNames=ZBT109_1922 {ECO:0000313|EMBL:BBG30668.1};
OS Zymobacter palmae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Zymobacter group; Zymobacter.
OX NCBI_TaxID=33074 {ECO:0000313|EMBL:BBG30668.1, ECO:0000313|Proteomes:UP000267342};
RN [1] {ECO:0000313|EMBL:BBG30668.1, ECO:0000313|Proteomes:UP000267342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAM14233 {ECO:0000313|EMBL:BBG30668.1,
RC ECO:0000313|Proteomes:UP000267342};
RA Yanase H.;
RT "Zymobacter palmae IAM14233 (=T109) whole genome analysis.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; AP018933; BBG30668.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A348HGB6; -.
DR STRING; 1123510.GCA_000620025_02047; -.
DR KEGG; zpl:ZBT109_1922; -.
DR OrthoDB; 9801120at2; -.
DR Proteomes; UP000267342; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR012726; ThiH.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR02351; thiH; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF1; 2-IMINOACETATE SYNTHASE; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00301; 2-iminoacetate_synthase_(ThiH); 1.
DR SFLD; SFLDG01081; cleavage_of_the_Ca-Cb_bond_in; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000267342};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 72..293
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 372..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 46565 MW; BFBE530EA87F3F1B CRC64;
MSRSFFGELH QLDWQDITLR INAMTAADVQ RALTTPSPDA HDLMALISPA ADGFLEQMAQ
RAQALSRQRF GSTIGMYVPL YLSNMCANNC SYCGFSSHNR ITRKILSGEE IERECEAIKA
LGFDQVVIVT GEHPKKVGMA YFREHLPRIR RHFSHLMMEV QPMRIEDYTE LRTLGVDTVL
VYQETYHPAL YDQHHLSGFK TDFQWRLETP DRLGLAGMSK IGLGALLGLS ADWRTDCFMM
TEHLRYLRER YWQSRFSISF PRLRPCEGGI TPAALVTERH LVQLICAYRI AFPDVELSLS
TRESARFRDH VAPLGITSIS AFSQTQPGGY ANTHDHHLEQ FTPDDHRTPE QVAEALRQSG
LQPVWKDWDA GFGRQAPSIR SSSDSSDTLS EHPHPVRHTR PATHEEQQA
//
