ID   A0A363RP43_9GAMM        Unreviewed;       790 AA.
AC   A0A363RP43;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:PWB18719.1};
GN   ORFNames=DCO49_19360 {ECO:0000313|EMBL:PWB18719.1};
OS   Stenotrophomonas sp. SPM.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Stenotrophomonas.
OX   NCBI_TaxID=2170735 {ECO:0000313|EMBL:PWB18719.1, ECO:0000313|Proteomes:UP000250746};
RN   [1] {ECO:0000313|Proteomes:UP000250746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SPM {ECO:0000313|Proteomes:UP000250746};
RA   Frantz D.C., Newman J.D.;
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWB18719.1}.
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DR   EMBL; QETL01000167; PWB18719.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A363RP43; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000250746; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          10..192
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          195..293
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   790 AA;  85894 MW;  FB8EC7C3FEEF0EBB CRC64;
     MSNSLLVRRA AVLGAGVMGA QIAAHLTNAG VDTVLFDLPA KEGPADGIVL KAIANLGKLS
     PAPLASKSLA EAITPANYES GLDQLKGCDL IIEAIAERMD WKQDLYKKIA PFVADHAVLA
     SNTSGLGINK LADVLPEQLR HRFCGVHFFN PPRYMHLAEL IPATTTDAAV LEGLEAFLVT
     TLGKGVVYAK DTPNFIGNRI GVFSILSTIH HTQEFGLGFD EVDGLTGPLV GRPKSATYRT
     SDVVGLDTMA HVIKTMGDTL PNDPWHEYFK SPKWLDALIS KGALGQKTGA GIFRKVGKDI
     VVLDLEKQDY RPADRTAAPE VVEILKIKNP AEKFAKLRES QHPQAQFLWA TFRDLFHYSA
     YHLADIAETA RDVDLAIRWG YGWSLGPFET WQAAGWKQVA QWIADDIVAG KSMSSAPLPD
     WVFDGRDGVH AAEGSYSPSR NAKLPRSALP VYQRQRFPDP LLGEKFAPGE TVFENDGLRM
     WHDGDGIAVV SFKTKMNTVS DQVLDGLQEC VSRAEKDFQG LVIWQQKEPF SAGADLAGAL
     GLLQAGKVDQ FEEMVANFQR TSQRIKYSLV PVVAAVRGLA LGGGCEFQMH SAKTVAFLES
     YIGLVEAGVG LLPAGGGLKE LAVRASQAAG PGGDVFAELK KTFETVAMAK VSNSAVNAQE
     LGLLRSTDKV VFNSYEALYI AKAEARALAE AGYRPPLPAR RIQVAGDVGI ATFKMMLVNM
     LEGRFISPYD YEIAERIATV LCGGKVDRGT LVDEEWLLTL ERKHFVELAQ QEKTQARIAH
     MLKTGKPLRN
//