ID A0A363RYH7_9GAMM Unreviewed; 549 AA.
AC A0A363RYH7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:PWB23161.1};
GN ORFNames=DCO49_14415 {ECO:0000313|EMBL:PWB23161.1};
OS Stenotrophomonas sp. SPM.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Stenotrophomonas.
OX NCBI_TaxID=2170735 {ECO:0000313|EMBL:PWB23161.1, ECO:0000313|Proteomes:UP000250746};
RN [1] {ECO:0000313|Proteomes:UP000250746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SPM {ECO:0000313|Proteomes:UP000250746};
RA Frantz D.C., Newman J.D.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|RuleBase:RU366002}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU366002}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU366002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWB23161.1}.
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DR EMBL; QETL01000073; PWB23161.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A363RYH7; -.
DR Proteomes; UP000250746; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR InterPro; IPR004709; NaH_exchanger.
DR NCBIfam; TIGR00831; a_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449, ECO:0000256|RuleBase:RU366002};
KW Cell inner membrane {ECO:0000256|RuleBase:RU366002};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU366002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 31..49
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 55..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 84..105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 111..135
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 183..204
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 216..234
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 240..259
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 271..292
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 312..335
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 356..383
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT DOMAIN 10..420
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 549 AA; 59928 MW; 4B5D70E4DBB20B21 CRC64;
MHTIEVVLAM LVAVVASGYL VRVLPFSLPL PLVQIALGAV IAGVFNRGHA LEPEVFFLLF
LPPLLFLDGW RIPKQGLFRD KGAILELAFG LVVFTVLGAG LLIHWMIPVM PLAVCFALAA
IVSPTDPVAV GAIAAKAPIP KRLMHILEGE SLLNDASGLV CFRFAVAAVM TGSFSLATAS
LTFLWVAVAG LAVGVAVTLG VSTFQRWLWR RFGEEPGAAM LVNLLIPFAA YLLAEEIHAS
GILAAVAAGI AMSYVELTGR VSGSMRVQRA GVWNMLQFSF NGIMFVLLGE QLPGIVERAT
TTMNETGHQS AWWLLVYVLV INAALIALRL LWVWLSLRWN LLRARRRGLE RGEAPNWRIV
VATSVAGVRG AITLAGVLTL PLFLPDGSAF PARDLVIFLA AAVILFSLVG ASVALPQLLK
GLQLPADSGE RKEEDLARKL SSKAALAGVE RMRQQLVMNQ NTENVQLYND AASRVSLLYQ
RHLEKDSDGP DVDPEKVNRM EQGYRQLRSA GLNAEREELF RLTRRGVISD EISRRLIRNL
DLLESRKRD
//
