ID A0A364L1K1_9EURO Unreviewed; 654 AA.
AC A0A364L1K1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN ORFNames=BHQ10_005704 {ECO:0000313|EMBL:RAO69692.1};
OS Talaromyces amestolkiae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=1196081 {ECO:0000313|EMBL:RAO69692.1, ECO:0000313|Proteomes:UP000249363};
RN [1] {ECO:0000313|EMBL:RAO69692.1, ECO:0000313|Proteomes:UP000249363}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIB {ECO:0000313|EMBL:RAO69692.1,
RC ECO:0000313|Proteomes:UP000249363};
RX PubMed=28649280; DOI=10.1186/s13068-017-0844-7;
RA de Eugenio L.I., Mendez-Liter J.A., Nieto-Dominguez M., Alonso L.,
RA Gil-Munoz J., Barriuso J., Prieto A., Martinez M.J.;
RT "Differential ?-glucosidase expression as a function of carbon source
RT availability in Talaromyces amestolkiae: a genomic and proteomic
RT approach.";
RL Biotechnol. Biofuels 10:161-161(2017).
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAO69692.1}.
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DR EMBL; MIKG01000010; RAO69692.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A364L1K1; -.
DR STRING; 1196081.A0A364L1K1; -.
DR OrthoDB; 49016at2759; -.
DR Proteomes; UP000249363; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 2.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000249363}.
FT DOMAIN 22..254
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 362..597
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 73..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 654 AA; 71962 MW; C6341B8E03826AB5 CRC64;
MDDITQELHE LFASSAPNGL AQDVLTELQS MLRLHGITPQ ELFYKWESYS MKMGSEDTKL
DLNTVRAFKR DVQDSLERET RGKNHQVRGS EKKSGVTATP RAGKTDVFGM LDDLTPGTPQ
SRINGSAKRK STFETPSGPK TVRTDGNGTP TGIKTPSAST NGMLSVAFAE RQNPGQLIET
LNAHLDLPKT PMAPFPEPRI RPTANTDLKK FGYKPMSMRL NEASEILDDR LDEFTDLFEK
QYPDATFGSA ATQSTSEIVA VGRIASDTLE GKLNVASLVL ETSRRTGAGL RVPLKVDALP
SVQFFPGQIV ALRGINASGE YFSVKEVLPL SLLPTAASYP STLETINERL GGVDVDQPLN
IFYAAGPYTA DDNLDFEPLQ ELCKKAAEEY ADALLLLGPF IDLEHPLIAT GDFDLPDIPG
LDPETATLTT LFRHCISKPL HQLCAAVPSI TIMLMPSVRD AVSKHVSWPQ EQFPKKELGL
PKQARVVSNP VTLSLNESVI GMCSHDVLYD LRKEEVLGGR PAEANLLTRL PRYIIEQRHF
APMFPPSSRD TLPKSGGPDS MLPIGGMMDV SYLKLGDWLN VRPDILITPS MLPPFVKVVE
SVLVINPGTL SKRRAAGTYA NMALYPRSIS EEERQEKQLS HKVFERARVD IVRI
//
