ID A0A364NE70_9PLEO Unreviewed; 1386 AA.
AC A0A364NE70;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|RuleBase:RU366037};
GN ORFNames=DDE83_001262 {ECO:0000313|EMBL:RAR15433.1};
OS Stemphylium lycopersici.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Stemphylium.
OX NCBI_TaxID=183478 {ECO:0000313|EMBL:RAR15433.1, ECO:0000313|Proteomes:UP000249619};
RN [1] {ECO:0000313|Proteomes:UP000249619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIDEFI 213 {ECO:0000313|Proteomes:UP000249619};
RA Medina R., Franco M.E.E., Lucentini C.G., Saparrat M.C.N., Balatti P.A.;
RT "Draft genome sequence of Stemphylium lycopersici strain CIDEFI 213.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease. {ECO:0000256|ARBA:ARBA00025147}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the esterase D family.
CC {ECO:0000256|ARBA:ARBA00005622}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|ARBA:ARBA00009466, ECO:0000256|RuleBase:RU366037}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAR15433.1}.
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DR EMBL; QGDH01000012; RAR15433.1; -; Genomic_DNA.
DR STRING; 183478.A0A364NE70; -.
DR Proteomes; UP000249619; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0018738; F:S-formylglutathione hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046294; P:formaldehyde catabolic process; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000801; Esterase-like.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR014186; S-formylglutathione_hydrol.
DR InterPro; IPR040017; XPOT.
DR NCBIfam; TIGR02821; fghA_ester_D; 1.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF00756; Esterase; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Hydrolase {ECO:0000313|EMBL:RAR15433.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000249619};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 453..596
FT /note="Exportin-1/Importin-beta-like"
FT /evidence="ECO:0000259|Pfam:PF08389"
FT DOMAIN 693..1381
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
FT ACT_SITE 152
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR614186-1"
FT ACT_SITE 229
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR614186-1"
FT ACT_SITE 265
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR614186-1"
SQ SEQUENCE 1386 AA; 154851 MW; 91F7C87AB74EB912 CRC64;
MSFETTGTIA SFGGKLLKLK HKSASTNTDM ELNMFLPPQA LKSGAKVPVL FYLSGLTCTG
NNCSEKGFFQ HGAAQHGIAV VYPDTSPRGL SIEGEDEAYD FGSGAGFYVD ATKEPWTKGY
NMYSYITKEL PEALFSSFQE LDSSRVSITG HSMGGHGALT LFLKNPGKYK SVSAFAPIAN
PINCPWGQKA FKGYFGEDQQ QKWKEHDASE LVKQWKGPLE MLIDVGTGDN FYKQGQLLPE
NFIQAAKEAG NDKGIQLRMQ PDYDHSYYFM ASFADDHVAW AAKHLGAYPC TRRFRTLLND
PIALQSTEHL SNTSDAHYIA QTTSTPNLTL KLTRPALSKW RKWKTSRTDA VMPKVENAIQ
IAANPTSSQE LRGQALEYLN QLRSEGSAWQ AALALFTRDP RATDFVRHTS LDLVNNAIQE
HRLDEQSTAY IRDALMNHIR QSYVPGSGAA DTTHIQNKLM QTITYLFVAL YPSSWQSFFD
DFRALAGDQA TIGSVNTATT FLYIRMLVQV HDEIADQLVA RPEDEKKRNT ELKDLIRQRD
AQKIALSWQE ILGKWRETDL GLVEMCLRTI GRWVSWTDIN LIVNQAMITT FLEMAGQQGI
GDPESAAGKV RDAAIDTFSE IVGKKMSPSD KIDLITFLNL SEVVGQLISS PALAEFHSPN
YDNDLAETVA KLVNNIVFDI VRILENEAVE EHIRQRADDL IRIFTPYLLR FFADQYDEVC
SMVIPSLTDL LTFLRKLQKK TGSVPPQYAA VLPPVLDAII AKMKYDETAS WGEEGDQTDE
AEFLDLRRRL HVLQQTVTAI DENYYIETLS RLVNGTFGRL SQGDQSLNWR DLELALYEMY
LFGELAIRNQ GLYAKRQPSS AAAEQLVIMM NSMVDSGLAN YPHPAVQLQY MEICVRYYQF
FEQNPGLIPK LLENFVNLTH SEHVKVRSRS WYLFQRLVKH LRAQLGNVSY DIIQAVGDLL
TIKAELPDNS EDEMSSDEED QSADALFNSQ LYLFEAVGCI ASSNTVSVDN KKLYAQTIMS
PLFEDMQQTL PQARNGDERA TLQIHHIIMA LGTLARGYSD WVPSNNNSAV PQSEVADEFV
KASEAILVAV ESLNSSGSIR HAARFAFSRM IAVLGSRLLQ QLPSWIEGLL SLSSSMDEIS
TFLKVLGQVI FTFKSEIAGI LDTVMTPVLQ RIFTALAVVP AGTDDEIQLA ELRREYLNFI
VVVLNHGLGS VLVSNANQAT FEPVISSIET FARDTHDYQT ARLAIFVLIR MISVWGGPDK
VGPGANATPT SPDATQAPLP GFDNYVVDRF SPLAWSIPAS PGFNAKDAQA KQVLYEAANL
QHEIIKKVGE PYIERLKSDL AEMGVGDDGQ DQYLRTLAGS FEGPKKEKEW RNFYTQFVDR
MLASRA
//
