ID A0A364NGB0_9PLEO Unreviewed; 5301 AA.
AC A0A364NGB0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Nonribosomal peptide synthetase 2 {ECO:0000313|EMBL:RAR16296.1};
GN ORFNames=DDE83_000424 {ECO:0000313|EMBL:RAR16296.1};
OS Stemphylium lycopersici.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Stemphylium.
OX NCBI_TaxID=183478 {ECO:0000313|EMBL:RAR16296.1, ECO:0000313|Proteomes:UP000249619};
RN [1] {ECO:0000313|Proteomes:UP000249619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIDEFI 213 {ECO:0000313|Proteomes:UP000249619};
RA Medina R., Franco M.E.E., Lucentini C.G., Saparrat M.C.N., Balatti P.A.;
RT "Draft genome sequence of Stemphylium lycopersici strain CIDEFI 213.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAR16296.1}.
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DR EMBL; QGDH01000004; RAR16296.1; -; Genomic_DNA.
DR STRING; 183478.A0A364NGB0; -.
DR Proteomes; UP000249619; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 3.
DR CDD; cd19542; CT_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 6.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF2; FERRICROCIN SYNTHETASE (NONRIBOSOMAL PEPTIDE SIDEROPHORE SYNTHASE ) (EUROFUNG); 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 6.
DR SMART; SM00823; PKS_PP; 6.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000249619}.
FT DOMAIN 1517..1594
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2574..2647
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3648..3725
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4202..4278
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4761..4834
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 5301 AA; 588928 MW; 82F2EF2756ADEDDB CRC64;
MVHSNGVSQH LSIINERPSI LVGPSLLHEL VPRLNHDAIA IDFLENGSKR RKFSYKTLHS
LSDVLAVRIT EILAKLESAS SVIPVLLPQS PELYVVLLAI LKAGKAFCPL NLDTPIERLR
YILADISAGM LITSSSHEEL IRAATRIHVV SADREFLGRD DYSLGNIPQS DTNDLAYVLY
TSGSTGLPKA VSVSHHAVTQ SLLAHDRHIP EFSRFLQFAA PTFDVSIFEI FFPWFRGKTL
AGCTRAQMLD DLPGTIGNLH VDAAELTPTV VSNLLNGRSS VPGLKLLLTI GEMLTQRVID
EYGGNASKES ILWAMYGPTE AAIHCTLWPH FPTSSSTSTI GHPLDTVSAF VLATSPEQEH
SGSVEILPLG EVGELAIGGP QVAKEYLNRP DLTSTSFVEH QTQWLPASMI PSDVCFIDAM
PQLPSGKIDR NSLAQTYLHS GSNDAASPAI VDVGDPVSHS ILSVVRPHTS QNLRLETKLA
SAGLDSLKAI RVASALRKKG YELGAIEVLS AATLADLIEV CKTRKAEIVP VGKKRIPSEN
GTHAVSSHLD LRPTGIAYII PCTPLQEALL AETRNRPSAY CNWIEVEISV TCTYEDIEHA
LRRLAQNTEV LRTGFFTESQ NATVFSEVVW KELLVSQIRE VSSFSRQYLL ESDDDFLRPL
NIQVMTCLPR PRLLFQIHHA LYDGWSFDLL LRDLDKCLRG ERLKERPSFQ EVIRYYAAGD
RPSNYADARG YWATLLSDYI PTPLPNYHGK LTHSSATHRF LGRSTISRNE LFERARELSI
NPQVYFQAAT AYVLSLYNGA TDVVLGNVTS GRTIPVDGIE DVVGPCIATL PFRINFGDAR
CVRDILYGTQ QLNRESLRYS ELPLREIAKA AKIKPGLRLF EALFVWQQSI VSDVNSSLVA
KVVDSADELE FRITLEFEPV EEYISFRGTF DASTIPESQI QQLFRQIDEV VRAFMADVDR
GVDKINQCFT TPSLSIANPA PIRQRFIHGP SYAVERWALN DPDRTAIIFG HDLNGVMEVK
NKATYGVLNS RANQFARVLA EHGVGNDHLV CIIMEKSINL YTSILAILKL GCGYLPLVPD
TPVDRVKRIL SDAGVTVCVS ESSFSPDLRR ELSVDLIDFD LTNLADYCDQ NLDIPYNGKH
LAYAVFTSGS TGTPKGVLVT QDNLMSNLQY LSTVYPYSTD SRLLQACSQA FDVSVFEIFF
SWYAGICLCS ATKEHLFRDF EAAINHLGVT HLSLTPTVAT LVEPRNVPKV RFLVTAGEAL
TEHVRRRWAG KGLYQGYGPS ETTNICTVRS AVTPDDLINN IGAPFSNTSA LVLDPETETI
LPRGAVGELC FGGAQVFRGY LHRPELNAQK IIDHPIYGRI YRSGDMGILL PDDCILSTGR
TDDQVKIRGQ RVELGETTSV MLDHEAVRDC VTLALHHTNN IQILVSFWVP STASFNEFRS
LEPLEFVAAI RELFDLLSRR LPTYMIPSHL VPISLLPMTP QAKIDKRVLQ CLFKSLAEDV
LTHTTHSSGI READQGELSS QWERDVVKIL CKVLDAPPNE LLRTSSFFNL GLDSVSAIRF
CSELRKAKLG DFSVSTVLQN PSIANLASLE RSPLSSPKPK APSAEVTNLF GAEQFQHIRS
RFEEAGARVV KILPCTALQE AMISSGMSST ALTYCNVMSF DVRGDSNRLQ QCWNTVLHRH
EIFRTCFVAT DDPRYSFAQF VLQDYEAVWH DHSTEKDLHL RISKIISELM EANKPPLYLA
LEQGEESTKL LFCCHHALYD GIAISTLLGE IQQLYHGYQL PPPISFEVYL QHMLDQDFSK
LDEYWSDLFK DFEPAFFPNV TGKTLATQCN PATSSRSLDI PLETVRKACL ANSVSLLSVI
QTAWAKLLAL YTGQSDVCFG NVVSGRGFPE DGLDRLVAPC FNTLPVRANF NSNTSNRALM
DLLHNLNVEM LAYQLTPLRR LLKITSPETS RLFDTLLILQ QPTSPLDDSI WKLEQDLGEM
DVPVVCEIIQ DPLKNTLTLL LHYHTSLLSE FEASIMMETF NALLSSLVET PDSPASDTHM
VPSRLWAISN TEARQLEVDL NFLHSGFERI ALLHPDRIAL EFWHPQGENT TWSFQHLNWE
ANKIAHALIR AGAGPEDIVP VHIAKRPLYY ASILGVLKAG AAFAPVHPEL PEARKQLMFT
ELGPKLVLCC NESLVDKHLT DATVIEVGSL MLSEDSNPVV EGLKNTNLAY CLFTSGSTGV
PKAVSMEHHA PIQTIESSRS LVPWTPSSRL LQYAAITFDM CYYDCFLAWT LGFTLCAAEQ
GDLLDDLPRI TNALETDLLD LTPSVAVSLK RVDVPKVKWL YCIGEAMPPA VAKEWGDACV
NSYGPTEAAF CTTMSPVSRG GNTSIIGKPF STTSFAVFPM EGQTPLPVLS VGELYIGGAQ
LARGYLGKAD LTRERFVKRC GQRFYKSGDM VRMLSDGNFE FLGRRDDQVK IRGLRVELGE
INSIFEDHDP DVVSVTTQIL HKDATARPQL VSFLVLRRSI DPNNMFEFQR RFKKLANSHL
PSYMVPQFYL VVDKIPKSMA GKIDRKALTD IFRKCSDATQ LTNGVSNASE TQWSDIGLEV
REVLARLSKT SVHAISPETS IYQLGLDSIS AVQVASALRA RGHSISATDV LRHTTCEDLA
DHMGKTLGFK ASTIPQFDFK AFEKKHTANL LQDHGIQDNN VLTVRPATPL QNAMISQFLA
REGTVYMNYL QLQLVAGLDK RKLKDAWTSA MERHSMLRTG FIHVNDPLSS FAMIEFTQNS
ASLPWSVAQN DESPPVDQWL RQIQLQAVKE LHIPPWAIRI IEKEGHASLD LAIFHALFDA
QSLQQMLHDV AAFYHGQTLP RVHSLDEVLS NIMHLSKQAN SPEESFWADL GKLASTTRFP
NLTPLKCDPE PFSVCVRQSS KSLPELEAGC RRVNTTMQTV GIAGWLSLLS SYTGESSVTC
GVVLSGRTFE ATEKAVFPCI NTVPYACTVS DDRAKMLNSI TALNASIQEH QFTPLKDIQR
LMGFPNEVLF DTIFAYQKLA SDVSQCELWT VRDEKATIEY PISIELEPKN GRLVYRLTYL
PHIVPVEQAA LILTQLDHLV ESFVFHSETS TTMVEYSQLL HSITPPKEEE LVSDIKLLHE
LVESTAKKHP HRNAFEFTSK EHNKECSTKR WTYSELDHEG NKLSHLLAIH GISPGSLVGV
CFDKCPEASF AMLGTLKAGC AFVAIDPGAP AARQTFVIND SGAQAVLSMT SQSSGFRNTV
NVPVLDLDQV DWSSLPEHKL LYNQISPSDR SYCLYTSGTT GMPKGCELTH ENAVQAMLAF
QRLFAGHWDA NSRWLQFASF HFDVSVLEQY WSWSVGICVV SAPRDLIFED LAKSIRDLDI
THIDLTPSLA QILHPDEVPS LCRGVFITGG ESLKQEILDV WGPKSVIYNG YGPTEATIGC
TMYPRVPTNG KPSNIGPQFD NVGSLVLRPG SDIPVLRGGV GELCVSGKLV GKGYLNRPDL
TAERFPYLER FKERVYRTGD LVRILHDNTF QFLGRADDQV KLRGQRLEVA EINSVIKLSD
HGISDVATFV LKHPKQQKEQ LVSFLVCGKR SKAQPEVLLG DARELKSAKE VCHDKLPPYM
IPTHFVLLTA MPLNVNNKAD GRRLRQIYEA LSVSELQNSS ATSSSSDEPW SKKESDIRNV
LLQVLDISQG STTKNTSFFE LGMDSISVIG VAKALKQAGF AEATASTILR YPTVRRLTKA
LSGSNTVSGS RGSILAAQQS ISAIQHRYRR EVAETLSIEP SMIEALAPCT PLQQGMIARS
VERDEGLYFN SFRFKLHMKI NAQKLQEAWE RVSTSTQILR TVFVETEEGC VQAVLKGVHS
TNIIETSSDD KFLVNHADQL RQSWLDRNRA ELRCPVELHL ITTQSQKLLI LHIFHGLYDG
KSIALLMQKF LEFYNGRVLP HSVPSFHTAL PHGPLRMVDG AREFWLKQIS KNTVALPKLF
GESDQDTILV TRTLHGLENF DSIRRKLNVT GQAIVQACWL SVLQEHVKGD VATGIVVSGR
SIDLEGADRV IGPMFNTIPH HHRARRSESW SSITKRVHEF NMEAHLYQHT PLRDITKWCK
RSPSEPLFDN LLVYEVAQAS EKWAKNEIWE ILDGDTVADY PLAFEVEQRS DGDLELTLVA
RKDVADAHIA ASFLDQFEGA LNQVLEDPSS TLELPVNLGN AAVNTIVVNS KPDHDTNGTP
AFWWTDNAVV LREEITALTG NESESINETT SIFELGLDSI DAIKLSSKLK KRGVQLSVSG
IMHGLNIRRM VKNIASKDDT IKKSSTRSHL DLYKQKLSTH LGHYVHETDD AIEVLPPTPL
QEGMLSEMIA SDYMRYYNHD VLRLDPGTDI RKLKEAWTAV VAASPVLRTG FIEVDDPEID
ASFAQVIHPH PHDFWSQISS NTVPDFTSIF GKLRDHAIHR AISTPAFHLT FIDVSDQFYL
VLSMAHALYD GVSLGLLHDD VHRAYHNDFK ARPSYGPALD GILSASGPGA ASFWKDYLFG
AKSSAFSTEV DAPDATPRVV HRREKDSGVV LNDLQTFARN TNVSLQAVGQ TVFALVSASL
TGSLDVTFGS VLSGRDNEEI SQLMFPTMNT VAVRSILHGT GAEMLRYVQE NLTNIKRWQH
YPLRKALLQA GVEGKLFDSL FIYQKNLVQG ERRNERLYTS VEGHSDVEYS VCVEMEVVQE
TLVWRCAVKE GVFDSEGAQK LLNQMDEVLR VLMARPEASI MNTDAEGVSV CSLPASKPDD
ARITRNLEEV DGIPDDGTQD TVTISKIRKV LAAISKIPED EIAADMTIFH MGLDSISAIK
VSSLLRKEDI VLSVGEMLRA GSAEKMAKLV HTRAAESPKD DNNDQAILGV AMKDLDRTDI
LYRAGIDEKD IADITPVTAG QLYMLSMWLN TKGSNFYADF SYNMSGKKTF NDIRHAWEAL
LTANPSLRTC FALADDHRTP YVQIVLKEVE STIMDVTELD EDALHILMSS VTHPQPWAKL
LVSRTREGWN LRLKIHHALY DGVSLPLLMQ QLQDGCNGVA ILPSDTTISK FIAPSLSASV
LERRRTFWTS YLRNTTTMSL PQPASIPNKK TEIFKPSLLP TASLGTIARR NGVSTQAILL
AVYAKLYAEL KASKNSEDVV IGIYLANRSL PIKGIASAAI PTLNLLPLRV RMSPQRSTID
IAADMQRDLQ DISKPANAST SLYEIYQWTG IKVDTFVNFL SLPDIQDAEK TASDESKITI
KPVRQWSNAI SRESTIEYGS LEVSSGLVNK RANEAYLHAI DVEATISNGA LDVGVFAPTE
MLSLQDGEQL LEDLKRELEA L
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