ID A0A365HAK1_9ACTN Unreviewed; 729 AA.
AC A0A365HAK1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN ORFNames=DPM19_09405 {ECO:0000313|EMBL:RAY16042.1};
OS Actinomadura craniellae.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=2231787 {ECO:0000313|EMBL:RAY16042.1, ECO:0000313|Proteomes:UP000251891};
RN [1] {ECO:0000313|EMBL:RAY16042.1, ECO:0000313|Proteomes:UP000251891}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LHW63021 {ECO:0000313|EMBL:RAY16042.1,
RC ECO:0000313|Proteomes:UP000251891};
RA Li L., Xu Q.H., Lin H.W., Lu Y.H.;
RT "Actinomadura craniellae sp. nov. isolated from marine sponge Craniella
RT sp.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the radical SAM superfamily. Anaerobic
CC sulfatase-maturating enzyme family. {ECO:0000256|ARBA:ARBA00023601}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAY16042.1}.
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DR EMBL; QLYX01000003; RAY16042.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A365HAK1; -.
DR OrthoDB; 9782387at2; -.
DR Proteomes; UP000251891; Unassembled WGS sequence.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR026337; Mod_HExxH.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR026335; rSAM_SPASM_FxsB.
DR InterPro; IPR023867; Sulphatase_maturase_rSAM.
DR NCBIfam; TIGR04267; mod_HExxH; 1.
DR NCBIfam; TIGR04269; SAM_SPASM_FxsB; 1.
DR PANTHER; PTHR43273; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR PANTHER; PTHR43273:SF8; RADICAL SAM PROTEIN-RELATED; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01072; dehydrogenase_like; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000251891};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 1..224
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 729 AA; 77569 MW; BFE362F5CB7F661D CRC64;
MVKVHSRCNL SCDHCYVYEH ADQSWRRQPP AMAPATVRQA ARRIAEHAAA HRVDGVLVVL
HGGEPTLLGP AGLRAVLAEL RAAIEPVTRL DLRIHTNGVL LDERLCELFA EYGVRVGVSL
DGDRQANDLH RRYADGRSSH RQVLRGLALL RRPEYRHLYA GILCTVDLAA DPIRVYEALL
AERPPRIDLL LPHATWDAPP PRPAGVPTPY ADWLGRVHAR WTADGRPVPV RLFDSISAAA
RGGPSGSEAI GLDPVGLATV ETDGSWEQAD SLKTAFDGAA ATGMDVFSHS VDDLAAHPGA
AARRGGLAAL CATCRACPVV RICGGGLYAH RHRAGHGFDN PSVYCADLKA LIARTAGAPR
PQAPRHALPE GAFDALAAGP GDAAAVTALA EMRLSLTRAL VAAVAGAGEP NRLAADGWAL
LADLDTARPE AVRAAFMHPY TQAWAVRCLR PPAGADPELD RAHLAGVAAA AAMHAGERPD
LLLPVRDGAL HVPGHGALRV GAAGHAAPPR PEDGEWLPVR RAGGLAVDDL DPFRDCQDWP
AAGRLSPAGW DAWSAALEAA LGELRRELPG YAAGLDAGLR AVVPLRPDPA GHGRSGTARH
AFGAVAVALP PSAADLSVLL VHEFQHVKLS ALLDMYGLFD PAERVLLRVP WRPDPRPVEG
VLHGVYAHLA IAELWRVRAR AGRPGAEARF ERHRSEVRDA IEAVRATRAL TAHGERFVAG
MHATVTGWS
//
