ID A0A365HCY3_9ACTN Unreviewed; 389 AA.
AC A0A365HCY3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Probable acetyl-CoA acetyltransferase {ECO:0000256|ARBA:ARBA00040529};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
GN ORFNames=DPM19_02180 {ECO:0000313|EMBL:RAY16994.1};
OS Actinomadura craniellae.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=2231787 {ECO:0000313|EMBL:RAY16994.1, ECO:0000313|Proteomes:UP000251891};
RN [1] {ECO:0000313|EMBL:RAY16994.1, ECO:0000313|Proteomes:UP000251891}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LHW63021 {ECO:0000313|EMBL:RAY16994.1,
RC ECO:0000313|Proteomes:UP000251891};
RA Li L., Xu Q.H., Lin H.W., Lu Y.H.;
RT "Actinomadura craniellae sp. nov. isolated from marine sponge Craniella
RT sp.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAY16994.1}.
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DR EMBL; QLYX01000001; RAY16994.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A365HCY3; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000251891; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:RAY16994.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000251891};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:RAY16994.1}.
FT DOMAIN 5..257
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 267..387
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 86
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 345
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 375
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 389 AA; 40354 MW; A388AABF6726F1BF CRC64;
MPEAVIVSAV RTPIGTARKG TLTETPAEDL ATHVLREAVR RSGIAPERFD DVIFGESMYG
GGDLARHAAV AAGMTRVPGV SMNRHCASSL TAVGTAAANI RAGMDRAIVA GGVQSSSLMP
ALDWRIPLGD ATERRIAPTF PYTDDATDET AMTVGWNVAQ KYGLTREQMD AWALRSHQRA
VAATEAGVFA DEIVPIKVTR RDGSVVEFAA DEHPRATTSA EKMAALPPLR PDIEGFSITA
GNASGSNDGA AALAVVADDL ARAEGLRTLA TVRAWAAVGV EPKFTGVGAI DAATKVLERA
GLTTADIDLW EINEAFASVP VATCQVLKLD EDRVNVHGSG CSLGHPIAAT GARMLTTLAH
ELRRRGGGIG LATMCAGGGQ GGAVVIEVA
//
