ID   A0A365MK07_GIBIN        Unreviewed;       781 AA.
AC   A0A365MK07;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN   ORFNames=FPRO05_07095 {ECO:0000313|EMBL:RBA08815.1};
OS   Gibberella intermedia (Bulb rot disease fungus) (Fusarium proliferatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=948311 {ECO:0000313|EMBL:RBA08815.1, ECO:0000313|Proteomes:UP000251714};
RN   [1] {ECO:0000313|EMBL:RBA08815.1, ECO:0000313|Proteomes:UP000251714}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ITEM 2341 {ECO:0000313|EMBL:RBA08815.1,
RC   ECO:0000313|Proteomes:UP000251714};
RA   Almiman B.F., Shittu T.A., Muthumeenakshi S., Baroncelli R.,
RA   Sreenivasaprasada S.;
RT   "Genome sequence of the mycotoxigenic crop pathogen Fusarium proliferatum,
RT   strain ITEM 2341 from Date Palm.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RBA08815.1}.
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DR   EMBL; PKMI01000094; RBA08815.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A365MK07; -.
DR   Proteomes; UP000251714; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   Gene3D; 6.20.120.20; -; 1.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022955};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022955};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Steroid biosynthesis {ECO:0000256|ARBA:ARBA00022955}.
FT   DOMAIN          108..400
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          413..743
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   781 AA;  89171 MW;  C22CD2100E7C9321 CRC64;
     MVANSTGLEG SALTSRKRAA DSESEPLLKQ GQPFPKQPRI SSHLDTTRWR LKDDDSRHTW
     HYLENDDDVK EWPQSYAEKW YLNLPLDLPD LPTPDNPLAA AENGLDFFEK LQLPSGHWGC
     EYGGPMFLLP GIVMTWYVTR TPISSAKATA IYKYISARAH PVDGGWGLHI EGESSVFGTL
     MNYVALRLLG VDPEDPVLVK ARGTLHKMGG ALYAPHWAKF WMAVLGLMSW DIVNPVPPEF
     WLLPDWVPFA PWRWWIHIRM VFLPMGWLYS KRWSCEETDV IRSLKKEVFL EDYAKINWSS
     HRNSIGAIDN YHPKSWFLNA ANWVLANIWM PYLRPNFLKE KAEAWASKQV DMEDANTGYA
     CLAPVNAAMN TVMCYARDGP DNYGVQRHIE RLEEYLWVKD EGMLANGTNG VQCWDTAFLI
     QAVFEAGLHK NEKYRPMLMK SLHYLERQQI REDCVDQEVC YRQPRKGGWP FSNRDQGYGV
     SDCISEALKA IILLQKVGGL PEVLEDRRLF DAVDTLLLYQ NDNGGMSSYE KRRGGEWLEM
     LNAAEVFGRI MIEYDYPECT TACVTALSMF NKHWPDYRTD EVRTLIRTAA EWIKSNQAPD
     GSWYGSWGIC FTYAGMFALE SMKHIGQTYA TGENSRRGCD FFISKQRADG GWSESYKACE
     TMTYVEHPSG SLVVQTAWAL IGLMEAEYPH VEPLRRGIQF IMDRQKPNGE WLQEAIEGVF
     NKSCMISYPN YKFTFTIKAL GMFAKRFPEE KLVPSWAVAE NGTNGVKTNG VKTNGVKGKG
     N
//