ID A0A365P2F9_9FLAO Unreviewed; 775 AA.
AC A0A365P2F9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=DPN68_06355 {ECO:0000313|EMBL:RBA28690.1};
OS Flavobacterium tibetense.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=2233533 {ECO:0000313|EMBL:RBA28690.1, ECO:0000313|Proteomes:UP000253319};
RN [1] {ECO:0000313|EMBL:RBA28690.1, ECO:0000313|Proteomes:UP000253319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YH5 {ECO:0000313|EMBL:RBA28690.1,
RC ECO:0000313|Proteomes:UP000253319};
RA Xing P., Phurbu D., Lu H.;
RT "Flavobacterium tibetense sp. nov., isolated from a wetland YonghuCo on
RT Tibetan Plateau.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RBA28690.1}.
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DR EMBL; QLST01000006; RBA28690.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A365P2F9; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000253319; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000253319}.
FT DOMAIN 6..291
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 292..573
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 775 AA; 88248 MW; 87DDEF317B95D015 CRC64;
MQKYISQLNE AQQLPVLQKD GPMIVIAGAG SGKTRVLTVR IANLMSQGVD AFNILALTFT
NKAAREMKKR IADIVGSNEA KNLWMGTFHS VFAKILRIES EKLGYPSNFT IYDTQDSVRL
IGAIIKEMQL DKDIYKPKQI LGRISSYKNS LITVKAYFNN PELQEADAMS KKPRMGEIYQ
QYVERCFKSG AMDFDDLLLK TNELLNRFPD VLAKYQDRFR YILVDEYQDT NHSQYLIVRA
LSDRFQNICV VGDDAQSIYA FRGANINNIL NFQKDYESVQ MYRLEQNYRS SKNIVEAANN
VIDKNKTKLD KIVWTSNADG PKIKVHRSLT DSEEGRFVAA TIFEEKMRNQ MHNGEFAILY
RTNAQSRAME DALRKRDIPY RIYGGLSFYQ RKEIKDVLSY LRLVINPKDE EALVRVINYP
ARGIGGTTID KLTIAANHYK RSIFEVMEHI DKIDLKLNSG TKAKLTDFVN MIKSFQIINE
NQDAFYLTEH ITKKTGLVQE LKKDGTPEGI ARIENIEELL NGIKDFTEGQ KEIDGARGAL
AEFLEDVALA TDLDKDTGDD DRVALMTIHL AKGLEFPHVF IVGLEEDLFP SAMSLNTRSE
LEEERRLFYV ALTRAEHQAY LTYAQSRYRW GKLVDSEPSR FIEEIDSQYL EYLNPQDSGY
RYKPLMDVDV FGDIDKSKLR LAKPKTGTPP AYLTQDQPNP TANIRRLKPM TSNAGSSNVV
DANLAVGNIV MHERFGKGQI VNIEGIGADK KAEIRFDVGG LKKLLLRFAK LEVIG
//
