ID A0A365P5E5_9FLAO Unreviewed; 1116 AA.
AC A0A365P5E5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN ECO:0000313|EMBL:RBA29820.1};
GN ORFNames=DPN68_00920 {ECO:0000313|EMBL:RBA29820.1};
OS Flavobacterium tibetense.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=2233533 {ECO:0000313|EMBL:RBA29820.1, ECO:0000313|Proteomes:UP000253319};
RN [1] {ECO:0000313|EMBL:RBA29820.1, ECO:0000313|Proteomes:UP000253319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YH5 {ECO:0000313|EMBL:RBA29820.1,
RC ECO:0000313|Proteomes:UP000253319};
RA Xing P., Phurbu D., Lu H.;
RT "Flavobacterium tibetense sp. nov., isolated from a wetland YonghuCo on
RT Tibetan Plateau.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RBA29820.1}.
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DR EMBL; QLST01000001; RBA29820.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A365P5E5; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000253319; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000253319}.
FT DOMAIN 573..734
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 743..909
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1116 AA; 127645 MW; 108503A011FAA951 CRC64;
MKASNISQKY QKNTTVKLLS DALATRPKLF VSGLVGSSLS FVIEAVFQKT ELPILLLFND
KEEAAYYLND LEQLINDQDV LFYPGSYRRP YQIEETDNAN ILLRAEVLNR INSRKKPAII
VSYTDAIFEK VVTRKELEKN TLKLSVNEAV SIDFINETLF EYNFKRVDFV TEPGEFSVRG
GIVDVFSFSN DHPYRIEFFG NEVDSIRSFD VETQLSVEKL KKISIMPNVE NKMLQESRES
FLNYINEKTV LVIQNTELLG KNLNKLFDKA TEAFGKLSSD IKHAQPEELF LNEAQFLKRA
LDFSVIELNS PIFKSEKTFT FQIQPQPSFN KQFDLLLNNL GENHFNGITN YLFCSNENQA
NRFHDIFEDI DEENHESIRK QYKTLVFPLY QGFVDLENQI ACYTDHQIFE RYHKFSIKNG
YSKKQTITLK ELNSLTVGDY VTHIDHGIGK FGGLQKIEVE GKKQEAIKLV YADNDIVYVS
IHSLHKISKY NGKDGTPPKI YKLGSGAWKA LKQKTKARVK HIAFNLIQLY AKRRLDKGFA
FAPDSYLQKE LESSFIYEDT PDQITATLDV KMDMESDRPM DRLVCGDVGF GKTEVAIRAA
FKAVDNSKQV AILVPTTILA YQHFRTFSER LKDMPVKIDY LNRFRTAKQK AAILQELEEG
KLDILIGTHQ LVNKNVKFKD LGLLIIDEEQ KFGVNVKDKL KAISTTVDTL TLTATPIPRT
LQFSLMAARD LSVITTPPPN RYPIETQVVG FNEEIIRDAI SYEIERGGQV YFINNRIENI
KEVAGMIQRL VPNAKVGIGH GQLDGKKLEE LMLAFMEGEF DVLVATTIIE SGLDVPNANT
IFINNANNFG LSDLHQMRGR VGRSNKKAFC YFITPPYSAM TEEARKRIQA LTQFSELGSG
FNIAMKDLEI RGAGDLLGGE QSGFINEIGF ETYQKIMNEA IEELKENEFK DLYQDENDNE
TKEYVKDLQI DTDYEILFPD DYINNITERL NLYNELSQIK DEATLQQFEQ KLIDRFGALP
KPAIALLNSV RIKWKATAIG LEKVVIKQGK MVGYFISDQQ SDFYQTSRFM KVLQFVQQNG
NLCKMKEKET KNGLRLLLTF ENVKSINKAL ELLEGI
//
