ID   A0A365ZLE9_9ACTN        Unreviewed;      1243 AA.
AC   A0A365ZLE9;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Caspase family p20 domain-containing protein {ECO:0000259|PROSITE:PS50208};
GN   ORFNames=DEH69_11965 {ECO:0000313|EMBL:RBM19099.1};
OS   Streptomyces sp. PT12.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1510197 {ECO:0000313|EMBL:RBM19099.1, ECO:0000313|Proteomes:UP000252839};
RN   [1] {ECO:0000313|EMBL:RBM19099.1, ECO:0000313|Proteomes:UP000252839}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PT12 {ECO:0000313|EMBL:RBM19099.1,
RC   ECO:0000313|Proteomes:UP000252839};
RA   Devaraj K., Tan G.Y.A.;
RT   "Diversity of actinobacteria isolated from Cape Rachado, Malaysia.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RBM19099.1}.
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DR   EMBL; QEST01000096; RBM19099.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A365ZLE9; -.
DR   OrthoDB; 3197455at2; -.
DR   Proteomes; UP000252839; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000252839}.
FT   DOMAIN          5..138
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
SQ   SEQUENCE   1243 AA;  136759 MW;  BDEAD497723F22C5 CRC64;
     MTRLVRRRAL LIGNEHYDDS RFSPLPSTRA DIWGMEQVLR HRSIGGFVSI TSRENLTAAD
     MQEAVSEFLD ACEQDELALV YVSGHGARLV RDGGEFHFIA TDTDFDRIAE TGVSAGFVNE
     RLEQCWAPQK VVMIDCCRSG GFAVGLRTSD RQPDSVAKSA EQEQPLLTSR GVYVLSSSRA
     GEDSYADRDS TGEVQPSAFT AEVIEALRTG KVSKDGKGDV SVEDLFHYVN RRMRAQGARQ
     VPVKFAHGVD DRIVIADCPF GAAPLLTPLT RRPILSSAPQ ALAPTRKSAS SQPTWHQLLD
     YYRECVLSDE TETPLMSVGD HDTSYVCLSG SERLLSGDVD DDGCIPVPTK AGGLIESAVE
     QEAELWAGYP AVVLTGPRGG RPWRHPKFAP LLIRRVEVVS EDGRVRLKPF GPVQPHPQLA
     RDWLGDEEAA QLADTFQPTW HRGQHDRMAV EASKLLREEF EIPCIQELLP DQLADRIDIH
     TPGDGARNTA VLFTALPDTA YTRKLLDDFA GIAEQTDRIQ ATALAALSPD PAERTRALAL
     SEPEPTRLVT PLPCNEAQAA VLHSAMTRRL TVATGPPGTG KSQLVANLVA TAVTSGQSVL
     VASNNNEAVN EVWRRCDTLV PGSVIRTGSA KAKTGNYVET EAKGLDALRT APEPVPNVAT
     AAMNVDIARG QLARVRQDLA QVTMTEKDLL QAGQLREEHA AQLGRSVTEL TEVLSQARSH
     DQVEARARRL AHARFFGTWR RGRFLSKIGL KTFEGDRAEG CLALADFAAA EAAWRNGYAR
     VAHVDDTALA TTVGAAEAGV QNASRTLLES TVRSNARTGR QRIRNLLSAR DSNRTDWAAV
     REVLPAAPSW AVTSLSARRF PLGPALFDLV VIDEASQCAI PHVLPLLFRA RRALVIGDAM
     QLPHIAKISP EREALIRRKT GLRSGWLEKH RLVHRRHSAF HTAERSAGGT LLLDEHFRCH
     PHIAAVSNEL FYDQGLTVLT DTRDRPSLPR QPIFWSHVPG RATRPPYGGS WVNHDEIRQV
     DSFVRALLEE LPDEATIGVV TPFTPQADEL RAQLRQYGRQ RVRVGTVHTF QGGERDVMVF
     SLVAGEGMHD SAIGWVHRQL NLWNVAITRA RSHLIVVGDM NLWRRWGGVA SELLNAATTT
     GPRIEDHAGD DLLQRLYQVM CTQPGTTATL GESVHGHPVD VLVRSRDAAR PQAVLLDRGP
     DEGADEARHL RLMLHRRRLV DCGEESAHAL RYPAWRLYDT STR
//