ID A0A365ZRX5_9ACTN Unreviewed; 976 AA.
AC A0A365ZRX5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=AfsR family transcriptional regulator {ECO:0000313|EMBL:RBM21916.1};
GN ORFNames=DEH69_05180 {ECO:0000313|EMBL:RBM21916.1};
OS Streptomyces sp. PT12.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1510197 {ECO:0000313|EMBL:RBM21916.1, ECO:0000313|Proteomes:UP000252839};
RN [1] {ECO:0000313|EMBL:RBM21916.1, ECO:0000313|Proteomes:UP000252839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PT12 {ECO:0000313|EMBL:RBM21916.1,
RC ECO:0000313|Proteomes:UP000252839};
RA Devaraj K., Tan G.Y.A.;
RT "Diversity of actinobacteria isolated from Cape Rachado, Malaysia.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RBM21916.1}.
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DR EMBL; QEST01000051; RBM21916.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A365ZRX5; -.
DR OrthoDB; 3845029at2; -.
DR Proteomes; UP000252839; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 4.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW Reference proteome {ECO:0000313|Proteomes:UP000252839};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 4..105
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 4..105
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 976 AA; 104905 MW; 1FE4B6141477B5BD CRC64;
MAVGEGTTGG HTPALRFAVL GPVRAWLGER PLASGSPQQR ALLAALLLRR GRTATAQELV
TALWGADPPQ QAVAALRTYA SRLRRSLAPR SEVLVTDLGG YALRLGPFDE FDLDTVAKLT
AEAEKSAATG ELPRAHDLYG KALALWDGEA LGGMPGHESE MERDRLAEQH LLLREARLDV
GIQSGLHAES VSELTALTTA HPLRERLREL LMLALYRSGR QAEALAVYAD ARRLLIDELG
VEPRPELSDL QQRILNADTT LNQPTQQSAS AIPVVRPAQL PAAVPDFTGR KAFVAELGAQ
LASAEGRVMA VSAVAGIGGV GKTTLAVQVA HAAREHFPDG QLYVDLQGAG AAPSDPAAVL
GAFLRALGQQ DTGIPETLDE RAALYRSLLD GRRVLTLLDN ARDAAQVRHL LPGTPGCATL
ITSRVRMVDL AGAHLVDLDV MSPEEALTLF TRIVGPERVN AERNAAMDVV AACGFLPLAI
RIAASRLATR RTWTVATLAR KLSDERRRLD ELQAGDQAVK ATFELGYGQL EREQARAFRL
LGLADGPDIS LAAAGALLGR DPADTEHLLE TLVDTSLLES AAPGRYRFHD LVRLFARACA
ERDEQPPAER GAALARLLDF YLATTARVYA VQRPGDRLPD HLAPTASPGL GFAEPHAALD
WLFAEADCLL ACVRQQAEGE TLRACTDLLL AARDLDESGT FSRQFEQAAL TVLDAARRST
DPLVEGRVRL ALTHAYNLAW RLDEAEEQAR HAHLLGLEAN DPVSSCMAPN ERGGIAFHRQ
RYADAVEYLE YALAAFRRDG NRAGEASALT NLSRAHSSLG EHELAVRLAR EAIDRYVELG
SSLRLANGHY ALGVLLTAAG EHVAAFDELS AALAGFEENR QRVWVGMTYI RMAEATLGTD
APDGSAALAE RAVAQFRDVG NEWMQARALT VLGRALDAVG QPGRARACWQ QALTAFEKLG
STEAAEVRNL LGSVGV
//
