ID A0A365ZYR5_9ACTN Unreviewed; 358 AA.
AC A0A365ZYR5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Peptidase M48 domain-containing protein {ECO:0000259|Pfam:PF01435};
GN ORFNames=DEH69_00145 {ECO:0000313|EMBL:RBM24320.1};
OS Streptomyces sp. PT12.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1510197 {ECO:0000313|EMBL:RBM24320.1, ECO:0000313|Proteomes:UP000252839};
RN [1] {ECO:0000313|EMBL:RBM24320.1, ECO:0000313|Proteomes:UP000252839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PT12 {ECO:0000313|EMBL:RBM24320.1,
RC ECO:0000313|Proteomes:UP000252839};
RA Devaraj K., Tan G.Y.A.;
RT "Diversity of actinobacteria isolated from Cape Rachado, Malaysia.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003983};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU003983};
CC -!- SIMILARITY: Belongs to the peptidase M48 family.
CC {ECO:0000256|RuleBase:RU003983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RBM24320.1}.
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DR EMBL; QEST01000008; RBM24320.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A365ZYR5; -.
DR OrthoDB; 3541294at2; -.
DR Proteomes; UP000252839; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07326; M56_BlaR1_MecR1_like; 1.
DR Gene3D; 3.30.2010.10; Metalloproteases ('zincins'), catalytic domain; 1.
DR InterPro; IPR001915; Peptidase_M48.
DR PANTHER; PTHR34978; POSSIBLE SENSOR-TRANSDUCER PROTEIN BLAR; 1.
DR PANTHER; PTHR34978:SF3; SLR0241 PROTEIN; 1.
DR Pfam; PF01435; Peptidase_M48; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003983};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003983};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003983};
KW Reference proteome {ECO:0000313|Proteomes:UP000252839};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003983}.
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 34..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..187
FT /note="Peptidase M48"
FT /evidence="ECO:0000259|Pfam:PF01435"
FT REGION 325..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 358 AA; 37604 MW; 6C21E7AE95233BBA CRC64;
MGVFVFLPLV LPLTAWPIAR LAERHLHSRT ATRLLTCVAV VLALCGTVCL TLIMIVGTAQ
VPGNPLPDGW SDPEVREAVL FVGAVGGAAI PALVAVAAAC GHALWRQRRV RRAMERALAG
TPASPVVVLS DPRPYAYAWP GRRGTGRGRV VASTAVLDSL TGPERRVLFA HERAHLAGRH
HRYPLLARLA ARAQPLLRPL RTAVAHCAER WVDEDAADVM GDRRLVARAV GRAALVSLDA
PPPPLPALAA PGPVPRGVAA LLNAGSPARG WPPAHTPTAL AAWVAAGGAA VSTVSSLNAA
TALVLIPRAA TPSCGAPLAR RRRACLTGRT PWAAGRGRST PRGRPPSPGG RTCRRRRR
//
