ID A0A366CZ04_9NOCA Unreviewed; 3276 AA.
AC A0A366CZ04;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:RBO83051.1};
DE Flags: Fragment;
GN ORFNames=DFR74_12050 {ECO:0000313|EMBL:RBO83051.1};
OS Nocardia puris.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=208602 {ECO:0000313|EMBL:RBO83051.1, ECO:0000313|Proteomes:UP000252586};
RN [1] {ECO:0000313|EMBL:RBO83051.1, ECO:0000313|Proteomes:UP000252586}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44599 {ECO:0000313|EMBL:RBO83051.1,
RC ECO:0000313|Proteomes:UP000252586};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RBO83051.1}.
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DR EMBL; QNRE01000020; RBO83051.1; -; Genomic_DNA.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000252586; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd19540; LCL_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000252586}.
FT DOMAIN 514..590
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1580..1655
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2645..2721
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT NON_TER 3276
FT /evidence="ECO:0000313|EMBL:RBO83051.1"
SQ SEQUENCE 3276 AA; 350580 MW; E6C2408C98B33BFB CRC64;
MLTAAVESAA DEVAVRYAPS ADPESVIELT YRQLDEDSSR LARELIERGV GPGDVVAIGI
SRSVASVLSV WAIAKTGAAY VPADPNYPAD RIAHIVSDSG AVVGLTTMAH RRALGTGVYW
IELDDPVVAE RILHREHRPI SYADRVRPLD ERHPAYVIYT SGSTGKPKGV VVTHTGLAGL
VAAEREHYKI DGDARVLHVC SPNFDVSVLE LLLAFSAGAT LVIAPHTVFG GYELADLLAR
EQVTHMLITP GALESVDPAG LDELGTVVVA GEKFGPELVA RWADGTREFY NGYGPTEATI
LATSTAPLYP DEPITIGTAI PGVGAFVLDA RLRPVPAGVV GELYLSGPAL AQGYLNRPGL
TAERFVASPF GAQSGAPGAR LYRTGDLVRR NEADGTLEYL GRSDFQVKIR GLRIELGEID
NALTAHPDVD FAATLGRELP SGATALVSYV LPRTGATLDT AALTEFVGRT LPAYMVPTVI
MVLDEIPLTS VGKLDRAALP EPVFAAGEYR APSTPTEEMV AEVFAALLLR DDAEARVGAD
DDFFELGGNS LLAAQAIARV GAALGARVPM QLLFDASTVA GLAEELDRYV GTASARIALE
PRERPERVPL SYAQQRMWFL NRFDPASGVN NIPVAVRLSG ALDVAALNAA VADLVHRHEV
LRTVYPEFDG AGYQLVLPVE DPRAVPELGA EPVGASNLVE LVTTAVTAGF DVTAAPPIRL
RLLEIGESEH VLVCVVHHIA GDGFSMGPLT RDLMTAYADR VAGRAPQLAP LAVQYADYAL
WQREVLGTED DPESLLAQQV SFWRDRLAGL PDQLELPSDR PRPAVASYRG GVVRFEIGAE
THTALGEVAQ RHHSTLFMVV HTALAVLLAR LSGTEDIAIG TPVAGRGDAA LDDLIGMFVN
TLVLRDRVDP AATVDDLLET VRHGDLAAFG HADVPFERLV ELLDPVRSAA RHPLFQVMLT
FQNLERTELA LPGLTVSGVE MAVPLAKFDL QFAVAERVAP DGSLDGMSAE ITYATDLFDE
ATVRGFAERF ERVLAVLASD SAAVVGDIDL LTDAERAAVL RTWNDTAHPV PAETLVSLFE
RQRTATSYAT ALVFEGERLT YAEFGARVHQ LARHLLAAGV GPESLVALAI RRSTELVVAM
YAVLEAGAGY VPLDPDQPAE RIDYVLDTAR PALVLTTSRD GFGTAVAPVL EVDAPEIARY
DATPITAAER ARPIRPSDTA YVIFTSGSTG RPKGVAVSHS AIVNRLLWMQ DSYPLGADDV
VLQKTPATFD VSVWEFFWPL QAGARLVVAK PDGHRDPVYL AQVIAEHGVT TVHFVPSMLS
VFVSTLGEGA DAPRVRQVFA SGEALPAVTA RRLRELTGAR LHNLYGPTEA AVDVTYHEVV
DADEVSVPIG RPVWNTQVYV LDSRLRPVAP GVAGELYLAG DQLARGYLGR PDLTADRFLA
NPYGPGGSRM YRTGDLVTWT ADGELEYLGR TDFQVKLRGL RIELGEIEAA LLAQPGIAQA
VVVLRTDEHA GDQLVGYLVP EPDVTLETES VRKELTGALP GYMVPAALVV LDAFPVNASG
KLDRKALPAP VFGGSSEYRA PGTPIEQAVA EVFASLLGAG EVGLDDDFFA LGGNSLLATR
AVARLNAALD ANVEVRELFE APTVAALAAR VVPGVAVDIR PPLVAGPRPE RVPLSLAQQR
MWVLNRIDPG SAAYNIPFAI QLAGHLDVTA IGQAALDVLE RHEALRTRFP ADEDGKPYQE
VLSVASVLPE GLQSEQPAHI MGRVVELMGS GFDVTEHPPV RIALLNGGVP DKHLLVLVAH
HIVADGASLA PLARDLMTAY IARVEGEAPG WAPLPVQYAD FALWQREVVG AEDDPDSVAA
RQLAHWKQRL AGLTGAATVP QDRPHPPVPS MRGASVGVTL PADVHADLAR IAREQNSSLF
MVVHAALAVL LARLTGDTDV AIGTPIAGRG ERALDGLVGM FVNTLTLRTT VDPDATFADL
VRQARETDLD AFANADIPFE RVVETVAPGR AGSASPLFQA VLAFQNLERP TLELPGLTVG
VLDSEAIAAK FDLLLNVEPR HRADGAPDEL ATMFTYATDI FDDVTVRGFT RMLATVITAV
ATDPEQPVGA IDLLTPAERD RLRPNRIPVS RVVTLPQLLQ SAVHSSPDGL AVVEGDATER
FAQLTYTELE LRSTLLARHL IALGVGPESV VAIGIPRSVE SVLAVWAITK TGAAFVPVDP
GYPAERVAHM IADSGTVLGL TLSGARPALP GSVEWLTLDD IDFVRGLMVY SAKPIVDADR
VRPLRPEHPA YVIYTSGSTG TPKGVVVSHA GLSAFCDEQR ERYRVIPGMR TLHFASPSFD
ASILELLLAV GGGATMVLAT PDIYGGEQLA ALLRRERVTH AFITPAALAS MDPAGLDELR
VLVVGGEALP PDLLRRWAVP SGPGPRQFFN AYGPTEATVV SNITAPMGPD TPVTIGPPIR
GVAEYVLDQR LRPVPTGVVG ELYLSGAQLA RGYGGRFGLT ASRFVADPIA GGGARMYRTG
DLVRWTRDGD LEYVGRNDFQ VKVRGFRIEL GEIDAVLTDF EGLDFAATVG HELDGGATIL
ASYVHAAPGA TVDVAAVQRF AEERLPRHMV PTSITVLDEI PLTPSGKLDR RALPEPALQA
TEFRAPSGPA EELVARLFGE ALGTEEPVGA DDDFFALGGN SLIATQVMAR LGAELGGRFE
VRELFNAPTV AGLAERIQGA VAAPARPALV AGPRPERIPL SPAQRRYWFL NQFDTAASAV
DNIPLAVRLS GALDVDALGH AVADVVARHE VLRTTYPGGD DAPYQVIHPV PAVAPSLTPV
DVTEDELAGA VVEFALTTFD VTTEVPFAVR LLRLTPTEHV LAMVVHHVAA DGSSMNPLAR
DVMVAYAARM RGAAPEFTPL PLQYADYALW HDAVLGAEDD PESLAAQQIA YWRETLAGLP
DQLELPADRP RPPVQSFRGA TLRTVVSPRQ HAALHELARA HQSSLFMVVH AALAVLLARL
SGTDDIAVGT PLAGRGEREL DDLVGMFVNT VVFRTRIRPG ERFTELLAEV RERDLEAFAH
ADVPFERLVE VLNPQRSTAR NPLFQIGLSF QNLGETTFEL PGLTVGAVDF DANLAKTDLQ
LTVTDRYAED GTPAELVTEF GYATDLFDES TVQGFADRFA RVVDAIIADA TAPVGAIDLL
SDEESERILR AWNDTAHAVD TEATLVSLLD ASATRTPQAT ALVADRPDRP PLTLTYAELD
FRVNKLARYL IGRGVRPEDR VALAIRRSAD LVIAMY
//
