ID   A0A366DS97_9NOCA        Unreviewed;       462 AA.
AC   A0A366DS97;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=cystathionine beta-synthase {ECO:0000256|ARBA:ARBA00012041};
DE            EC=4.2.1.22 {ECO:0000256|ARBA:ARBA00012041};
DE   AltName: Full=Beta-thionase {ECO:0000256|ARBA:ARBA00030337};
DE   AltName: Full=Serine sulfhydrase {ECO:0000256|ARBA:ARBA00031579};
GN   ORFNames=DFR74_103421 {ECO:0000313|EMBL:RBO92775.1};
OS   Nocardia puris.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=208602 {ECO:0000313|EMBL:RBO92775.1, ECO:0000313|Proteomes:UP000252586};
RN   [1] {ECO:0000313|EMBL:RBO92775.1, ECO:0000313|Proteomes:UP000252586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44599 {ECO:0000313|EMBL:RBO92775.1,
RC   ECO:0000313|Proteomes:UP000252586};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT   most valuable type-strain genomes for metagenomic binning, comparative
RT   biology and taxonomic classification.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homocysteine + L-serine = H2O + L,L-cystathionine;
CC         Xref=Rhea:RHEA:10112, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384,
CC         ChEBI:CHEBI:58161, ChEBI:CHEBI:58199; EC=4.2.1.22;
CC         Evidence={ECO:0000256|ARBA:ARBA00001175};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the cysteine synthase/cystathionine beta-
CC       synthase family. {ECO:0000256|ARBA:ARBA00007103}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RBO92775.1}.
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DR   EMBL; QNRE01000003; RBO92775.1; -; Genomic_DNA.
DR   RefSeq; WP_067508237.1; NZ_QNRE01000003.1.
DR   AlphaFoldDB; A0A366DS97; -.
DR   STRING; 1210090.GCA_001613185_02580; -.
DR   OrthoDB; 9805733at2; -.
DR   Proteomes; UP000252586; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004122; F:cystathionine beta-synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019343; P:cysteine biosynthetic process via cystathionine; IEA:InterPro.
DR   CDD; cd01561; CBS_like; 1.
DR   CDD; cd04608; CBS_pair_CBS; 1.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR046353; CBS_C.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR005857; Cysta_beta_synth.
DR   InterPro; IPR001926; TrpB-like_PALP.
DR   InterPro; IPR036052; TrpB-like_PALP_sf.
DR   NCBIfam; TIGR01137; cysta_beta; 1.
DR   PANTHER; PTHR10314; CYSTATHIONINE BETA-SYNTHASE; 1.
DR   PANTHER; PTHR10314:SF194; CYSTATHIONINE BETA-SYNTHASE; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00291; PALP; 1.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR   PROSITE; PS51371; CBS; 1.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Reference proteome {ECO:0000313|Proteomes:UP000252586}.
FT   DOMAIN          338..400
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   462 AA;  48734 MW;  2FD6A59C5EFEE98F CRC64;
     MRIADHVVDL IGNTPLVRLN SVVGPNAGLV AAKIEYLNPG GSSKDRIAVK MIEAAERDGL
     LKPGGTIVEP TSGNTGVGLA LVAQQRGYKC VFVCPDKVSE DKRNVLRAYG AEVVVCPTAV
     PPDHPDSYYS VSDRLVDEIE GAWKPNQYSN PGGPESHYET TGPEIWRDTD GKVTHFVAGV
     GTGGTITGTG RYLKEVSGGK VKIIGADPEG SVYSGGTGRP YLVEGVGEDF WPTAYDPAVP
     DEIIAVSDAD SFDMTRRLAR EEGLLVGGSC GMAVVAAIEV ARRDPDAVVV VLLPDGGRGY
     LSKIFNDRWM SSYGFLRSRL DGSPEPLVGD VLRGKTGGLP DLVHTHPSET LRDAIEILRE
     YGVSQMPVVG AEPPVMAGEV AGSVTERDLL SAVFEGRAQL TDSVAEHMSP SFPLIGSGEP
     ISAATKALSD TDALMVVEDG KPVGVITRHD LLGFLSTGRI GA
//