ID   A0A366HK46_9BACT        Unreviewed;       680 AA.
AC   A0A366HK46;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Squalene-hopene/tetraprenyl-beta-curcumene cyclase {ECO:0000313|EMBL:RBP42614.1};
GN   ORFNames=DES53_106323 {ECO:0000313|EMBL:RBP42614.1};
OS   Roseimicrobium gellanilyticum.
OC   Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC   Verrucomicrobiaceae; Roseimicrobium.
OX   NCBI_TaxID=748857 {ECO:0000313|EMBL:RBP42614.1, ECO:0000313|Proteomes:UP000253426};
RN   [1] {ECO:0000313|EMBL:RBP42614.1, ECO:0000313|Proteomes:UP000253426}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 25532 {ECO:0000313|EMBL:RBP42614.1,
RC   ECO:0000313|Proteomes:UP000253426};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT   most valuable type-strain genomes for metagenomic binning, comparative
RT   biology and taxonomic classification.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004999}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RBP42614.1}.
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DR   EMBL; QNRR01000006; RBP42614.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A366HK46; -.
DR   OrthoDB; 9758578at2; -.
DR   UniPathway; UPA00337; -.
DR   Proteomes; UP000253426; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR001330; PFTB_repeat.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF00432; Prenyltrans; 2.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE   4: Predicted;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          32..161
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          314..430
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   680 AA;  74584 MW;  2B0AA1B117EF41C6 CRC64;
     MARGCFFPTT SALSAAPTSS SKVSLFELDA AIASTRSYLL SLRNAQGHWE GYLSSSALST
     ATAIVALRQV DAAKHELVIA RGAAWLVKNQ NEDGGWGDTT LSKSNLSTTL LCWSALRMFD
     GQSDIANEGV AIDRANHWIA SQVGSLDPED ITEAVVARYG KDKTFSVPIL MLCAICGTLG
     EDHEAWSKVL PLPFELAALP RSWFGAVGLP VVSYALPALI AIGHARFVHA PPGKWNPLRL
     IRGALWGRIY PMLKTLQPSS GGYLEATPLT SFVTMALASS GDKDHPCVPA AVEFLLKSER
     EDGSWPIDTN LATWGTTLAT KALLGGDSEG EAEQETERAT LRKELRPVRE WLLKQQYREV
     HPFTNAAPGG WAWTDLPGGV PDADDTSGAV VALAYLCETD EERREALPAA EAGITWLLDL
     QNRDGGMPTF CRGWGTLPFD RSTPEIMAHA LRGWAAWEPY VNEALRERMR GAKTRALAYL
     SKMRWRVWKS GTGYVSPYGD QVMLKTKQRL RLGSLHWWQP LWFGNEHTPV ENNPVFGTAL
     VLMGLLHADL TLEGGSVWGV PSISLQMHLR WLVEQQGDDG GWGGDKGVVP SVEETSVVVH
     VLSLTLQRMG ATWEHEVRAN ALGAVERGVT WLLKKTRNGA EFPSAPIGLY FARLWYHEMI
     YPVVWSLGAL RAAREVLSRV
//