ID A0A366K981_9BIFI Unreviewed; 308 AA.
AC A0A366K981;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Tyrosine recombinase XerD {ECO:0000256|ARBA:ARBA00015810, ECO:0000256|HAMAP-Rule:MF_01807};
GN Name=xerD {ECO:0000256|HAMAP-Rule:MF_01807};
GN ORFNames=CRD60_03600 {ECO:0000313|EMBL:RBP98229.1};
OS Bifidobacterium aemilianum.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=2493120 {ECO:0000313|EMBL:RBP98229.1, ECO:0000313|Proteomes:UP000252530};
RN [1] {ECO:0000313|EMBL:RBP98229.1, ECO:0000313|Proteomes:UP000252530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XV10 {ECO:0000313|EMBL:RBP98229.1,
RC ECO:0000313|Proteomes:UP000252530};
RA Alberoni D., Baffoni L., Di Gioia D., Gaggia F., Biavati B.;
RT "Bifidobacterium xylocopum sp. nov. and Bifidobacterium aemilianum sp.
RT nov., from the carpenter bee (Xylocopa violacea) digestive tract.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC the cutting and rejoining of the recombining DNA molecules. The XerC-
CC XerD complex is essential to convert dimers of the bacterial chromosome
CC into monomers to permit their segregation at cell division. It also
CC contributes to the segregational stability of plasmids.
CC {ECO:0000256|HAMAP-Rule:MF_01807}.
CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC molecules of XerC and two molecules of XerD. {ECO:0000256|HAMAP-
CC Rule:MF_01807}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01807}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD subfamily.
CC {ECO:0000256|ARBA:ARBA00010450, ECO:0000256|HAMAP-Rule:MF_01807}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RBP98229.1}.
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DR EMBL; PDCG01000002; RBP98229.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A366K981; -.
DR OrthoDB; 9801717at2; -.
DR Proteomes; UP000252530; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006313; P:DNA transposition; IEA:UniProtKB-UniRule.
DR CDD; cd00798; INT_XerDC_C; 1.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR HAMAP; MF_01808; Recomb_XerC_XerD; 1.
DR HAMAP; MF_01807; Recomb_XerD; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR InterPro; IPR011932; Recomb_XerD.
DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR NCBIfam; TIGR02225; recomb_XerD; 1.
DR PANTHER; PTHR30349; PHAGE INTEGRASE-RELATED; 1.
DR PANTHER; PTHR30349:SF87; PROPHAGE INTEGRASE INTD-RELATED; 1.
DR Pfam; PF02899; Phage_int_SAM_1; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW Rule:MF_01807};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW Rule:MF_01807};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829, ECO:0000256|HAMAP-
KW Rule:MF_01807};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01807};
KW DNA integration {ECO:0000256|ARBA:ARBA00022908, ECO:0000256|HAMAP-
KW Rule:MF_01807};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172, ECO:0000256|HAMAP-
KW Rule:MF_01807};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01807}; Reference proteome {ECO:0000313|Proteomes:UP000252530}.
FT DOMAIN 2..88
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 109..301
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
FT ACT_SITE 152
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807"
FT ACT_SITE 176
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807"
FT ACT_SITE 253
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807"
FT ACT_SITE 256
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807"
FT ACT_SITE 279
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807"
FT ACT_SITE 288
FT /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01807"
SQ SEQUENCE 308 AA; 34054 MW; F36623E54DE073BE CRC64;
MTDTDRLLVQ FIAHIDVERG LAASTVAAYR ADIERYLQWL KSRGKADLAQ VGRQDVEDYI
AVLDQAGESS RSKARRLASL HEFHRFALAQ HAVEDDVSAG VKAPKASGHL PDVLSVDEVR
RLLEAADLGG GHDPVALRDS ALLEFMYATG CRVSEAVGAD LSDLDMDEQV VRLMGKGSKE
RLVPFGAYAR QSLDDYLAGG RQALEAKGRG KGSPERRAIF LNKRGRRLSR QSVWEITRQA
GERAHIDRPL HPHTLRHSYA THLIQGGADV RTVQELLGHA SVTTTQIYTH VSPENLIETY
LSSHPRAR
//
