ID   A0A366W9M9_9RHOB        Unreviewed;       422 AA.
AC   A0A366W9M9;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Insulinase family protein {ECO:0000313|EMBL:RBW45759.1};
GN   ORFNames=DS901_01060 {ECO:0000313|EMBL:RBW45759.1};
OS   Loktanella sp. D2R18.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Loktanella.
OX   NCBI_TaxID=2267230 {ECO:0000313|EMBL:RBW45759.1, ECO:0000313|Proteomes:UP000253154};
RN   [1] {ECO:0000313|EMBL:RBW45759.1, ECO:0000313|Proteomes:UP000253154}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D2R18 {ECO:0000313|EMBL:RBW45759.1,
RC   ECO:0000313|Proteomes:UP000253154};
RA   Enke T.N., Datta M.S., Schwartzman J.A., Cermak N., Schmitz D.A.,
RA   Barrere J., Cordero O.X.;
RT   "Modular assembly of carbohydrate-degrading microbial communities in the
RT   ocean.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RBW45759.1}.
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DR   EMBL; QOCG01000004; RBW45759.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A366W9M9; -.
DR   OrthoDB; 9811314at2; -.
DR   Proteomes; UP000253154; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR11851:SF149; GH01077P; 1.
DR   PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
FT   DOMAIN          13..160
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          167..340
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   422 AA;  45855 MW;  6540F4ACCD1004D8 CRC64;
     MTIQLHTLSN GFRIVTEHMP TLKSASIGIW VEAGGRHEKP AQNGIAHFLE HMAFKGTQKR
     TALQIAECIE DVGGYINAYT SREATAYYVR LLENDVPLGL DVIADILLNP VFAPEDIEIE
     RGVILQEIGM TIDTPDEMVF DWLQEVSFPD QALGRTILGP AERVSAFNRD DLQQFVGQHY
     GPNQMILAAA GAVDHDAIVA QAEALFGHLP ALDRGTDLIQ PARFGGGEIR NVKDLEQVHF
     ALGLEGPNYR DPQIYTAQIY SSVMGGGVSS RLFQEIRENR GLCYSIFAQT GAYEDTGMTT
     IYAGTSAEQI AELATVTIDE MKRAADDMTA SEVARARAQM KAGLLMGLES PSNRAERLAR
     LLQIWGRIPS LDETIAQIDA VTTGDVKSFA GQMAGQTGMG LALYGPTDAA PTLDALKERL
     AA
//