ID   A0A366ZNF8_9ACTN        Unreviewed;       305 AA.
AC   A0A366ZNF8;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Flap endonuclease {ECO:0000313|EMBL:RBY78814.1};
GN   ORFNames=DQ238_11710 {ECO:0000313|EMBL:RBY78814.1};
OS   Geodermatophilus sp. TF02-6.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Geodermatophilus.
OX   NCBI_TaxID=2250575 {ECO:0000313|EMBL:RBY78814.1, ECO:0000313|Proteomes:UP000253027};
RN   [1] {ECO:0000313|EMBL:RBY78814.1, ECO:0000313|Proteomes:UP000253027}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TF02-6 {ECO:0000313|EMBL:RBY78814.1,
RC   ECO:0000313|Proteomes:UP000253027};
RA   Ennis N., Dharumadurai D., Sevigny J., Hall J., Simposon S., Morris K.,
RA   Thomas W.K., Tisa L.S.;
RT   "Genome Sequence of Geodermatophilus sp. TF02-6.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RBY78814.1}.
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DR   EMBL; QOHF01000011; RBY78814.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A366ZNF8; -.
DR   OrthoDB; 9806424at2; -.
DR   Proteomes; UP000253027; Unassembled WGS sequence.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   CDD; cd09859; PIN_53EXO; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646:SF2; DNA-DIRECTED DNA POLYMERASE; 1.
DR   PANTHER; PTHR42646; FLAP ENDONUCLEASE XNI; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Endonuclease {ECO:0000313|EMBL:RBY78814.1};
KW   Hydrolase {ECO:0000313|EMBL:RBY78814.1};
KW   Nuclease {ECO:0000313|EMBL:RBY78814.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253027}.
FT   DOMAIN          1..270
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00475"
SQ   SEQUENCE   305 AA;  31663 MW;  9689CBFC8CCCC5C4 CRC64;
     MLLDAASLYF RAFYGVPTSV TSPDGRPVNA VRGFLDMIAR LVTAHRPERL VACWDDDWRP
     AFRVAALPSY KAHRLGPDGG EQTPDELGPQ VPVLVEVLAA AGIARVGAPG YEADDVIATL
     AARARGPVDV VTGDRDLFQL VDDERGVRVL YTARGITDIE AVDEAAVTAR YGIPGRAYAD
     FAVLRGDPSD GLPGVAGVGA KTAAALVTAF GDLAGIRAAA ARTVVPEAPL TAAVLRRLSA
     GADYLDAAPV VVAVARDIDL PPVDDVLPRR PDDPEALAAL AAAHGLQSSI RRLGAALGWP
     AAATG
//