ID A0A366ZX21_9ACTN Unreviewed; 666 AA.
AC A0A366ZX21;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Acetoacetate--CoA ligase {ECO:0000313|EMBL:RBY81628.1};
DE EC=6.2.1.16 {ECO:0000313|EMBL:RBY81628.1};
GN ORFNames=DQ238_06215 {ECO:0000313|EMBL:RBY81628.1};
OS Geodermatophilus sp. TF02-6.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Geodermatophilus.
OX NCBI_TaxID=2250575 {ECO:0000313|EMBL:RBY81628.1, ECO:0000313|Proteomes:UP000253027};
RN [1] {ECO:0000313|EMBL:RBY81628.1, ECO:0000313|Proteomes:UP000253027}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TF02-6 {ECO:0000313|EMBL:RBY81628.1,
RC ECO:0000313|Proteomes:UP000253027};
RA Ennis N., Dharumadurai D., Sevigny J., Hall J., Simposon S., Morris K.,
RA Thomas W.K., Tisa L.S.;
RT "Genome Sequence of Geodermatophilus sp. TF02-6.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RBY81628.1}.
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DR EMBL; QOHF01000005; RBY81628.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A366ZX21; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000253027; Unassembled WGS sequence.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:RBY81628.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000253027}.
FT DOMAIN 46..102
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 113..482
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 548..623
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 666 AA; 72240 MW; 74890DF453151452 CRC64;
MSADTSAEPA VLWRPTPESM RATRLAEFAG WVAGRRGLDF GDPPDYDAIW RWSVEHLDQF
WADVAAWSGV LPGVPDDRVL TRREMPGAEW FPDATLNYAE QALRHAADGT VPADSPALVA
VAEDAEPTEV SWATLRAQVG AFAATLRRLG VRRGDRVAGY LPNVPEAVVA FLGTAAVGAV
WSSCAPDFGT RAVLDRFAQI EPTVLVAVDG YRWGGREYDR RDVVAELRAA LTSVRTTIAV
PRLHPDEVPD GALPWGEAVA DEQEPQFEQL PFDSPLWIVY SSGTTGLPKG IVHGHGGITV
EQHKQLALHG DVRPGDRFYW YASTAWIMWN IATSALLCGA TVVVHDGAPT YPSVDAQFAI
AAQTRLTYLG TSAGYLTTCE KAAARPGETH DLSALRSIGS TGSPLPASAF EWVYDAVEAD
VFLGSLSGGT DVATGFIGSS LLLPVTAGEL QRPMLAVAAA AWDEQGRPVV GELGELVVTE
PMPTMPLYFW NDPDGARYRE TYFEPWPGVW RHGDWMEVTE RGTCIITGRS DSTLNRGGVR
MGTADIYAAV ESVPEVLDCV VLGVEQRDGG YWMPLFVQLA PGEELTDELQ ARIREAIRRQ
ASPRHVPDEV LAVPAVPHTR TGKRLEVPLK RLFQGVDPAR ALNVGAVDDP AAVEHYVALA
RERGPR
//
