ID   A0A366ZY02_9ACTN        Unreviewed;       447 AA.
AC   A0A366ZY02;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Insulinase family protein {ECO:0000313|EMBL:RBY82142.1};
GN   ORFNames=DQ238_06015 {ECO:0000313|EMBL:RBY82142.1};
OS   Geodermatophilus sp. TF02-6.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Geodermatophilus.
OX   NCBI_TaxID=2250575 {ECO:0000313|EMBL:RBY82142.1, ECO:0000313|Proteomes:UP000253027};
RN   [1] {ECO:0000313|EMBL:RBY82142.1, ECO:0000313|Proteomes:UP000253027}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TF02-6 {ECO:0000313|EMBL:RBY82142.1,
RC   ECO:0000313|Proteomes:UP000253027};
RA   Ennis N., Dharumadurai D., Sevigny J., Hall J., Simposon S., Morris K.,
RA   Thomas W.K., Tisa L.S.;
RT   "Genome Sequence of Geodermatophilus sp. TF02-6.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RBY82142.1}.
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DR   EMBL; QOHF01000004; RBY82142.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A366ZY02; -.
DR   OrthoDB; 9811314at2; -.
DR   Proteomes; UP000253027; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR11851:SF149; GH01077P; 1.
DR   PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000253027}.
FT   DOMAIN          39..186
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          193..373
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   REGION          238..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   447 AA;  47768 MW;  A1471F031C526024 CRC64;
     MTTDTQQVPA PAGVGQTVVL DVDEFGGRVE RTELPGGLRV LTETMPGVLS ATVGIWVGVG
     SRDETDAVAG ASHFLEHLLF KGTGTRSALE IATAMDAVGG EMNAFTAKEH TCYYANVLAS
     DLPLAVTLLG DLVTDALNTA ADLQSERTVV LEEIAMRDDE PADSVHDLFA ETLFGGTALG
     RSVLGTVASI EALTRDDVDG WYRSRYAVPS VVVTAAGRVE HRQVLDLVTA AFGSRLSGPG
     RPAPLRRGDE RSPTRPARPT GLIRRRTEQT HLLLGSVGVG RLDDRRYAAA VMETAVGGGM
     SSRLFQEIRE KRGLVYSVGS SLSHYAGTGS FSVYAGCSPK RVPGVLRLVR EELARVAADG
     LTPEEVARGR GQLKGGMVLG LEDTGSRMSR LGKSELSHGE YLPVREVLDR LDAVDEDQVR
     EVAADLLTRE TCLAVVGPYR ESELDRL
//