ID A0A367AEC3_9ACTN Unreviewed; 544 AA.
AC A0A367AEC3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Bifunctional 3'-5' exonuclease/DNA polymerase {ECO:0000313|EMBL:RBY87794.1};
GN ORFNames=DQ241_11060 {ECO:0000313|EMBL:RBY87794.1};
OS Blastococcus sp. TF02A-30.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Blastococcus.
OX NCBI_TaxID=2250580 {ECO:0000313|EMBL:RBY87794.1, ECO:0000313|Proteomes:UP000253175};
RN [1] {ECO:0000313|EMBL:RBY87794.1, ECO:0000313|Proteomes:UP000253175}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TF02A-30 {ECO:0000313|EMBL:RBY87794.1,
RC ECO:0000313|Proteomes:UP000253175};
RA Ennis N., Dharumadurai D., Sevigny J., Morris K., Simpson S., Thomas W.K.,
RA Tisa L.S.;
RT "Genome Sequence of Blastococcus sp. TF02-30.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RBY87794.1}.
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DR EMBL; QOHJ01000004; RBY87794.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367AEC3; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000253175; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50890; PUA; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:RBY87794.1};
KW Hydrolase {ECO:0000313|EMBL:RBY87794.1};
KW Nuclease {ECO:0000313|EMBL:RBY87794.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253175}.
FT DOMAIN 298..503
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 544 AA; 58694 MW; AE63F685DB5151C9 CRC64;
MNRIVLVRRG GDVVEAREGD VVTRVPAAGL AGFVGRRETG PVRWVWDDTT RWYPELLRQG
VRVARCTDLR LTHALLRRSP FADQSLLAAD ETAAWDALQP VTDDAPALFP LDDPADRLDA
VAEDARQQAA VAASPERGRL ALLLAAESSG ALVAAEMTHS GLPWRVDVHE AILTGLLGPR
PVAGQRPAVL ERLAGEIRAA LGAPALNPDS PAELLRALQA AGLPVEDTRS WTLEQLDHAV
VAPLLEYKKL ARLMTANGWA WLDAWVREGR FRSWFVVGGV VTGRWASNGG GALSVPAQVR
PAAVADEGWR FVVADVAQLE PRVLAAMSGD AAMAEAARAT DLYEGMVTAG AVASRAEAKV
GMLGAMYGGT RGESGRMMPR LTRRYPRAIG LVEEAARAGE RGEVVRTLLG RGSPAPTGAW
AQRGADLGEA PEQAGRDADR HRRAWGRFTR NFVVQGTAAE WALCWLADLR NRLWRLGEGD
LRDRPHLVFF LHDEVLVHTP EHLADAVAEE VRLAAAEAGR LLFGGFPVDF PLDVAVVRSW
ADAG
//
