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Database: UniProt
Entry: A0A367AYM6_9ACTN
LinkDB: A0A367AYM6_9ACTN
Original site: A0A367AYM6_9ACTN 
ID   A0A367AYM6_9ACTN        Unreviewed;       916 AA.
AC   A0A367AYM6;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=DNA polymerase I {ECO:0000256|RuleBase:RU004460};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU004460};
GN   Name=polA {ECO:0000256|RuleBase:RU004460};
GN   ORFNames=DQ237_16205 {ECO:0000313|EMBL:RBY93725.1};
OS   Blastococcus sp. TF02-8.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Blastococcus.
OX   NCBI_TaxID=2250574 {ECO:0000313|EMBL:RBY93725.1, ECO:0000313|Proteomes:UP000252403};
RN   [1] {ECO:0000313|EMBL:RBY93725.1, ECO:0000313|Proteomes:UP000252403}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TF02-8 {ECO:0000313|EMBL:RBY93725.1,
RC   ECO:0000313|Proteomes:UP000252403};
RA   Ennis N., Dharumadurai D., Sevigny J., Hall J., Morris K., Simpson S.,
RA   Thomas W.K., Tisa L.S.;
RT   "Genome Sequence of Blastococcus sp. TF02-8.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In addition to polymerase activity, this DNA polymerase
CC       exhibits 5'-3' exonuclease activity. {ECO:0000256|RuleBase:RU004460}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU004460};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705, ECO:0000256|RuleBase:RU004460}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RBY93725.1}.
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DR   EMBL; QOHK01000009; RBY93725.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A367AYM6; -.
DR   OrthoDB; 9806424at2; -.
DR   Proteomes; UP000252403; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR   CDD; cd06140; DNA_polA_I_Bacillus_like_exo; 1.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   CDD; cd09859; PIN_53EXO; 1.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR018320; DNA_polymerase_1.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   NCBIfam; TIGR00593; pola; 1.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF27; DNA POLYMERASE NU; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU004460};
KW   DNA repair {ECO:0000256|RuleBase:RU004460};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU004460};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004460};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU004460};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU004460};
KW   Reference proteome {ECO:0000313|Proteomes:UP000252403};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004460}.
FT   DOMAIN          22..284
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00475"
FT   DOMAIN          672..879
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   916 AA;  99582 MW;  31B410B930CF80E9 CRC64;
     MSAPVSTSVS TPAPTTASAP GTRPRLLLLD GHSLAYRAFF ALPVENFSTT TGQPTNAVYG
     FTSMLINILR DEQPSHLAVA FDVGRKTFRS EIYAEYKANR SESPTDFRGQ VSLVQEVLGA
     LRVPVITAEG YEADDVIATL TVQAVEQGMD VLIATGDRDA LQLVNEHVTV LYPRKGVSDM
     TRFTPEEVEA KYNLTPAQYP DFAALRGDPS DNLPSIPSVG EKTAAKWVRE YGSLDALVDQ
     VDTVKGKVGE KLREHLSSVL QNRRLTELDR AVPLEVGPQD LAVQAWDRNE VHTLFDNLQF
     RVLRERLFAT LTSAEPEVEG GFDATVDAVA AGELGAWLDA HARTGHTGLI FRGTWGRGTG
     ELTGLALAAA DDHTTFVDLG PALDVADEQA LAAWLADADR PKVVHEVKGP LLAIWARGWE
     LAGLVSDTAL AAYLALPGQR SFDLGDLAVR YLRRELTDAA EPEGQLTLDG LGPSEDDVAA
     EAAKADVLKA VAVNDLADAL EQVLGQKGGD HLLGEIELPL TRVLASMEYR GIAVDLDFLQ
     DLQKEFSDAV AAAAAECYAV IGREVNLGSP KQLQAVIFDE LGLPKTKKNK TGYTTDADAL
     TWLFEQTGHP FMEHLLRHRD VTRLRTVIDG LIPMVDDGGR IHTTFQQTIA ATGRLSSTDP
     NLQNIPIRSA EGRRIRQAFV VGQGYESLMT ADYSQIEMRI MAHLSGDEGL IEAFTSGEDL
     HSFVASKAFD IPISEVDPEM RRRIKAMSYG LAYGLSAYGL SGQLRISVEE AREQMNAYFE
     RFGGIRDYLD GVVDEARQTG FTETTLGRRR YLPDLTSDNG QRRQMAERMA LNAPIQGSAA
     DVIKVAMLNV EKAIAAEGLR SRMLLQVHDE LVLEVAPGEE EALETLVRRE MAGAAQLSVP
     LEVSVGVGAS WDAAAH
//
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