ID A0A367B528_9ACTN Unreviewed; 1109 AA.
AC A0A367B528;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=DQ237_07535 {ECO:0000313|EMBL:RBY96490.1};
OS Blastococcus sp. TF02-8.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Blastococcus.
OX NCBI_TaxID=2250574 {ECO:0000313|EMBL:RBY96490.1, ECO:0000313|Proteomes:UP000252403};
RN [1] {ECO:0000313|EMBL:RBY96490.1, ECO:0000313|Proteomes:UP000252403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TF02-8 {ECO:0000313|EMBL:RBY96490.1,
RC ECO:0000313|Proteomes:UP000252403};
RA Ennis N., Dharumadurai D., Sevigny J., Hall J., Morris K., Simpson S.,
RA Thomas W.K., Tisa L.S.;
RT "Genome Sequence of Blastococcus sp. TF02-8.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RBY96490.1}.
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DR EMBL; QOHK01000003; RBY96490.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367B528; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000252403; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000252403}.
FT DOMAIN 43..378
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 379..693
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 64..71
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1109 AA; 118783 MW; 850BAEF595FF6AB6 CRC64;
MSRHDDGQLS FEELFAEADV VESAPRRLLS PAEVAQRCGL SYAPSDEQAG VVSAPADRPL
VVVAGAGSGK TETMAARVSS LVANRIVEPE AILGLTFTRK AASELNERIR LRLGALARHP
DTEEDLRERL AIAQPTVSTY HGYAASLVSE HGLRIGVEPG AGVLGPAMCW GQAATVVAAW
TGDMSDVPLT LLTTVEDVLA LATELGEHDV TPAALRTWTA RLEAQITGYA DAPKKRGPYA
AVTEMLNRQK ARVALLPLVE AFEARKRALG SIDYADQVAY AARIAVSSPE VGRRERARWK
VVLLDEYQDT SVGQLRMLEA LFGGASGHPV LAVGDPRQSI YGWRGASAGT IERFARTFPG
RPGRTSERLT LATSWRNDEA VLAVANAVSA MLPEPAQPLP DLAPAPTAGR GSVTVGLYET
VAEETAALAD RMAACWNGTD ALVPRKADGR PPSMAVLVRT RKQLPGIAAA LRERGLPVEV
VGLGGLLEVP EVSDVVATLT VLVDPTAGDA MGRLLTGARW RIGPRDLAAL EARARALVHS
RRPPRQSDGE SAAVVEAPQE RGSIVEALDD LGDAEQYSAT GFRRLRRFGA ELAHLRNRIG
ESLPDLVDEV ARTLGLETEL ASVPGVSPAG ARAHLDALHQ VAAEFTELAE LPSLPAFLGY
LRDAEERERG LEPGEVAVNP EAVQLLTGHS AKGLEWDVVA VPGMTDGQFP ARTNASDSWI
KDPGAVPAEL RLTDRAELPA LELPVPGSGD QAAVRDALEQ YVQDWKDFGR DEEIRLGYVA
VTRARKLLLC SGSWWRDGVK PCGPSSLLET VKEACEAGAG ALLHWAPAPE DGATNPALEE
WPVGVWPVDP LSEPRRRALT AAAQLVEGAA PHPLDPERSL GDGDELVDQW VRDADLLLRE
RARHASPTVD VPLPSHLSVS ALVTLRRDPA ELARRLRRPM PAAPAPQARR GTAFHAWLEE
RFGAARLVDL DELPGSGDEL ATPDGALEEL REAFLASEWA DRQPLEVEVP FETPLGPLTL
RGRIDAVFRR EDGGYEVIDW KTGPPPTAGE MAAAGVQLAA YRLGWARLTG VPVEQVSAGF
HHVSAKETIR PVDLLDEAGL LALVVGSEQ
//