ID A0A367EGY6_9ACTN Unreviewed; 599 AA.
AC A0A367EGY6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Bifunctional 3'-5' exonuclease/DNA polymerase {ECO:0000313|EMBL:RCG17334.1};
GN ORFNames=DTL70_27595 {ECO:0000313|EMBL:RCG17334.1};
OS Streptomyces diacarni.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2800381 {ECO:0000313|EMBL:RCG17334.1, ECO:0000313|Proteomes:UP000252914};
RN [1] {ECO:0000313|EMBL:RCG17334.1, ECO:0000313|Proteomes:UP000252914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LHW51701 {ECO:0000313|EMBL:RCG17334.1,
RC ECO:0000313|Proteomes:UP000252914};
RA Li L.;
RT "Streptomyces reniochalinae sp. nov. and Streptomyces diacarnus sp. nov.
RT from marine sponges.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCG17334.1}.
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DR EMBL; QOIN01000055; RCG17334.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367EGY6; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000252914; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:RCG17334.1};
KW Hydrolase {ECO:0000313|EMBL:RCG17334.1};
KW Nuclease {ECO:0000313|EMBL:RCG17334.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000252914}.
FT DOMAIN 342..558
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 599 AA; 63854 MW; BB1801BCE131A773 CRC64;
MTNGTGANGT EAGAGGAHTT RRARDARRWA LAPAGGGRVR VCPLDARGGR AGPVRTEESA
AAAVRAGEGV TRWVWRATTE VQPGLLAAGV RVERCYDVEA AEALLLGHEG RAGDPHALPA
ALARLRGLPV PPDRQPVHRE TDPQPSLFET GPVPLPDGVD PLDALLEVYA AQVERTERAE
HPARMRLLLA GESAGTLVAG EMGHAGVPWS AEIHRELLAE LLGERYAGGG LPRRLVELEE
EVSRAFGPHE RVRPDLAADV LQAFARQGIR LGSTRAWELR KVDHPAVEPL LRYKKLYRLY
TAHGWSWLRS WVREGRFRPE YVPGGAASGR WTTNGGGALQ IPKVVRRAVV ADPGRRLVVA
DADQMEPRVL AAVSRDPGLM AVAGSERDLY TALSERAFSG DRAQAKLALL GAVYGQTSGD
GLRNLAALRR RFPAAVAYVD EAARAGEEGR LVRTHLGRTC PPVGREDGGA PADEASGTGP
EAGEGFAGTE GESGTAGARA AGAVRARGRF TRNFVVQGSA ADWAVLMLAG LRQRLAELTA
ELVFFQHDEV IVHCPAEEAD PVREAIDAAG RQAARAAFGD TPVRFPFTTA VVRCYADAK
//
